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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The efficacy of artemether in the treatment of plasmodium falciparum malaria in sudan
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 87, No. 6, Year 1993
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Description
The efficacy of artemether (a qinghaosu derivative) administered intramuscularly for the treatment of Plasmodium falciparum malaria was compared to quinine in an open randomized trial including 54 patients in eastern Sudan, where chloroquine resistance is common. The artemether treatment (5 d intramuscular regimen) was effective and the drug was well tolerated. All patients had cleared the parasitaemia and were free of symptoms 48 h after initiation of treatment. The parasite clearance time was comparable in patients receiving artemether and quinine. No side effect was reported by patients receiving artemether. No recrudescence was seen in 21 patients treated with artemether who completed 28 d follow-up. In the quinine group 3 of 18 patients had recrudescences, or possibly reinfections, on days 14, 21 and 28. © 1993 Oxford University Press.
Authors & Co-Authors
el-Hassan, Ibrahim M.
Denmark, Copenhagen
Københavns Universitet
Sudan, Khartoum
Malaria Administration
Satti, Gwiria M.H.
Sudan, Khartoum
Khartoum University
Ali, Abed Elkarim
Sudan
Gedaref Teaching Hospital
Fadul, Insaf A.
Sudan, Khartoum
Khartoum University
Elkhalifa, Ali A.
Sudan, Khartoum
Khartoum University
Abedelrahim, Abedelrahim M.
Sudan
Gedaref Teaching Hospital
Ming, Chen
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
G. Theander, Thor Grundtvig
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Statistics
Citations: 21
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(93)90293-Y
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Sudan