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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Tracing pastoralist migrations to southern Africa with lactase persistence alleles
Current Biology, Volume 24, No. 8, Year 2014
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Description
Although southern African Khoisan populations are often assumed to have remained largely isolated during prehistory, there is growing evidence for a migration of pastoralists from eastern Africa some 2,000 years ago [1-5], prior to the arrival of Bantu-speaking populations in southern Africa. Eastern Africa harbors distinctive lactase persistence (LP) alleles [6-8], and therefore LP alleles in southern African populations may be derived from this eastern African pastoralist migration. We sequenced the lactase enhancer region in 457 individuals from 18 Khoisan and seven Bantu-speaking groups from Botswana, Namibia, and Zambia and additionally genotyped four short tandem repeat (STR) loci that flank the lactase enhancer region. We found nine single-nucleotide polymorphisms, of which the most frequent is -14010*C, which was previously found to be associated with LP in Kenya and Tanzania and to exhibit a strong signal of positive selection [8]. This allele occurs in significantly higher frequency in pastoralist groups and in Khoe-speaking groups in our study, supporting the hypothesis of a migration of eastern African pastoralists that was primarily associated with Khoe speakers [2]. Moreover, we find a signal of ongoing positive selection in all three pastoralist groups in our study, as well as (surprisingly) in two foraging groups. © 2014 Elsevier Ltd.
Authors & Co-Authors
Macholdt, Enrico
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Lede, Vera
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Barbieri, Chiara
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Mpoloka, Sununguko Wata
Botswana, Gaborone
University of Botswana
Chen, Hua
United States, Berkeley
University of California, Berkeley
Slatkin, Montgomery
United States, Berkeley
University of California, Berkeley
Pakendorf, Brigitte
France, Lyon
Université Lumière Lyon 2
Stoneking, Mark
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Statistics
Citations: 110
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.cub.2014.03.027
ISSN:
09609822
Research Areas
Genetics And Genomics
Study Locations
Botswana
Kenya
Namibia
Tanzania
Zambia