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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Epidemiology of acute leukaemia in the Cape Province of South Africa
Leukemia Research, Volume 16, No. 10, Year 1992
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Description
Of 535 consecutive cases of acute leukaemia diagnosed in the Cape Province between 1978 and 1985, demographic data are incomplete in 75 black patients and they have had to be excluded from the spatial analysis. Of the remaining 460 cases, 223 (48.5%) occurred in white patients and 237 (51.5%) in those of mixed ancestry, classified as coloureds according to the Population Registration Act No. 30 of 1950. The average incidence was 2.12, 1.37 and 0.58/100 000 for whites, coloureds and blacks respectively. There was no temporal trend in the incidence of acute leukaemia between the three race groups. The median age for whites was 30 years and for the coloureds was 15 years, which is comparable to the 16 years for the black patients. The two-peak age distribution for leukaemia was seen in the white group, but was absent in the other two groups. This is accounted for by a different distribution in non-lymphoblastic as opposed to lymphoblastic subtypes. Furthermore, there was a disproportionately high frequency of acute progranulocytic leukaemia in the black patients, whereas the white and coloured groups were similar. There was a single, clearly defined macro-scale cluster restricted to white patients in Statistical Region 17 (SR-17). This exploratory study provides the first epidemiologic data for acute leukaemia in the Cape Province. It needs to be extended in order to verify these observations under more controlled circumstances and to seek evidence for some environmental factors that may account for the geographical cluster. © 1992.
Authors & Co-Authors
Sayers, Gwen M.
South Africa, Cape Town
University of Cape Town
Rip, Michael Russell
South Africa, Cape
Community Health
Jacobs, Peter B.
South Africa, Cape Town
University of Cape Town
Klopper, Jack M.L.
South Africa, Cape
Community Health
Karabus, Cyril D.
South Africa, Cape
The Departments of Haematology
South Africa, Observatory
Groote Schuur Hospital
Rosenstrauch, Willem J.
South Africa, Cape
Clinical Haematology and Oncochemotherapy
Hesseling, Peter Bernard
South Africa, Tygerberg
Tygerberg Hospital
Hoffman, Margaret N.
South Africa, Cape
Community Health
Sayed, Rauf
South Africa, Cape
Community Health
Statistics
Citations: 16
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/0145-2126(92)90074-H
ISSN:
01452126
Study Design
Cross Sectional Study
Cohort Study
Exploratory Study
Study Locations
South Africa