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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Breakdown in the process of incipient speciation in Anopheles gambiae
Genetics, Volume 193, No. 4, Year 2013
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Description
Understanding genetic causes and effects of speciation in sympatric populations of sexually reproducing eukaryotes ischallenging, controversial, and of practical importance for controlling rapidly evolving pests and pathogens. The major African malariavector mosquito Anopheles gambiae sensu stricto (s.s.) is considered to contain two incipient species with strong reproductiveisolation, hybrids between the M and S molecular forms being very rare. Following recent observations of higher proportions of hybridforms at a few sites in West Africa, we conducted new surveys of 12 sites in four contiguous countries (The Gambia, Senegal, Guinea-Bissau, and Republic of Guinea). Identification and genotyping of 3499 A. gambiae s.s. revealed high frequencies of M/S hybrid formsat each site, ranging from 5 to 42%, and a large spectrum of inbreeding coefficient values from 0.11 to 0.76, spanning most of therange expected between the alternative extremes of panmixia and assortative mating. Year-round sampling over 2 years at one of thesites in The Gambia showed that M/S hybrid forms had similar relative frequencies throughout periods of marked seasonal variation inmosquito breeding and abundance. Genome-wide scans with an Affymetrix high-density single-nucleotide polymorphism (SNP) microarrayenabled replicate comparisons of pools of different molecular forms, in three separate populations. These showed strongdifferentiation between M and S forms only in the pericentromeric region of the X chromosome that contains the molecular formspecificmarker locus, with only a few other loci showing minor differences. In the X chromosome, the M/S hybrid forms were moredifferentiated from M than from S forms, supporting a hypothesis of asymmetric introgression and backcrossing. © 2013 by the Genetics Society of America.
Authors & Co-Authors
Nwakanma, Davis C.
Unknown Affiliation
Neafsey, Daniel E.
Unknown Affiliation
Jawara, Musa
Unknown Affiliation
Adiamoh, Majidah
Unknown Affiliation
Lund, Emily
Unknown Affiliation
Rodrigues, Amabélia
Unknown Affiliation
Loua, Kovana Marcel
Unknown Affiliation
Konaté, Lassana
Unknown Affiliation
Sy, Ngayo
Unknown Affiliation
Dia, Ibrahima K.
Unknown Affiliation
Samson-Awolola, Taiwo
Unknown Affiliation
Muskavitch, Marc A.T.
Unknown Affiliation
Conway, David J.
Unknown Affiliation
Statistics
Citations: 54
Authors: 13
Affiliations: 12
Identifiers
Doi:
10.1534/genetics.112.148718
ISSN:
00166731
e-ISSN:
19432631
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Gambia
Guinea
Guinea-Bissau
Senegal