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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Screening of medicinal plants used in South African traditional medicine for genotoxic effects
Toxicology Letters, Volume 143, No. 2, Year 2003
Notification
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Description
Dichloromethane and 90% methanol extracts from 51 South African medicinal plants were evaluated for potential genotoxic effects using the bacterial Ames and VITOTOX® tests with and without metabolic activation. Dichloromethane extracts from bulbs of Crinum macowanii showed mutagenicity in strain TA98 with and without metabolic activation, whereas extracts from leaves of Chaetacme aristata and foliage of Plumbago auriculata showed mutagenicity and/or toxicity. Extracts from the leaves of Catharanthus roseus and twigs of Combretum mkhzense were mutagenic with metabolic activation only. The only 90% methanol extracts that were mutagenic in strain TA98 were from the leaves of C. roseus and Ziziphus mucronata in the presence of metabolic activation. No genotoxic effects were found in strain TA100 or in the VITOTOX® test. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
Authors & Co-Authors
Elgorashi, Esam E.
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Belgium, Ghent
Universiteit Gent
South Africa, Durban
University of Kwazulu-natal
Taylor, Joslyn L.S.
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Belgium, Ghent
Universiteit Gent
South Africa, Durban
University of Kwazulu-natal
Maes, Annemarie
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
van Staden, Johannes V.
South Africa, Durban
University of Kwazulu-natal
De Kimpe, Norbert G.
Belgium, Ghent
Universiteit Gent
Verschaeve, Luc
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Statistics
Citations: 176
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/S0378-4274(03)00176-0
ISSN:
03784274
Research Areas
Health System And Policy
Noncommunicable Diseases