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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Peripartum cardiomyopathy: Inflammatory markers as predictors of outcome in 100 prospectively studied patients
European Heart Journal, Volume 27, No. 4, Year 2006
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Description
Aims: Peripartum cardiomyopathy (PPCM) is a disorder of unknown aetiology with a course and outcome that is largely unpredictable. We evaluated the prognostic role of multiple inflammatory markers in the plasma of a large cohort of African patients with PPCM. Methods and results: The study of 100 patients with newly diagnosed PPCM was single-centred, prospective, and longitudinal. Clinical assessment, echocardiography, and blood analysis were done at baseline and after 6 months of standard therapy. Inflammatory markers were measured at baseline only. Fifteen patients died. Left ventricular ejection fraction (LVEF) improved from 26.2 ± 8.2 to 42.9 ± 13.6% at 6 months (P < 0.0001. However, normalization of LVEF (>50%) was only observed in 23%. Baseline levels of C-reactive protein correlated positively with baseline LV end-diastolic (rs = 0.33, P = 0.0026) and end-systolic (rs = 0.35, P = 0.0012) diameters and inversely with LVEF (rs = -0.27, P = 0.015). Patients who died presented with significantly lower mean EF and higher Fas/Apo-1 plasma values (P < 0.05). Fas/Apo-1 and New York Heart Association functional class (NYHA FC) predicted mortality at baseline. Conclusion: Plasma markers of inflammation were significantly elevated and correlated with increased LV dimensions and lower LVEF at presentation. Baseline Fas/Apo-1 and higher NYHA FC were the only predictors of mortality. Normalization of LVEF was only observed in 23% of this African cohort. © The European Society of Cardiology 2005. All rights reserved.
Authors & Co-Authors
Sliwa, Karen S.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Förster, Olaf
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Libhaber, Elena N.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Fett, James
Haiti, Deschapelles
Hospital Albert Schweitzer
Sundstrom, J. Bruce
United States, Atlanta
Emory University School of Medicine
Hilfiker-Kleiner, Denise
Germany, Hannover
Hannover Medical School
Ansari, Aftab Ab A.
United States, Atlanta
Emory University School of Medicine
Statistics
Citations: 307
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1093/eurheartj/ehi481
ISSN:
0195668X
e-ISSN:
15229645
Study Design
Cohort Study