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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Fast screening of whole blood and tumor tissue for bladder cancer biomarkers using stochastic needle sensors
Sensors (Switzerland), Volume 20, No. 8, Article 2420, Year 2020
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Description
Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Stefan-van Staden, Raluca Ioana
Romania, Bucharest
National Institute of Research for Electrochemistry and Condensed Matter
Gheorghe, Damaris Cristina
Romania, Bucharest
National Institute of Research for Electrochemistry and Condensed Matter
Statistics
Citations: 12
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.3390/s20082420
ISSN:
14248220
Research Areas
Cancer
Participants Gender
Male
Female