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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malaria
Journal of Nutrition, Volume 135, No. 4, Year 2005
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Description
Plasma concentrations of some micronutrients are altered in the setting of acute infectious or inflammatory stress. Previous studies have provided conflicting evidence concerning the extent and direction of changes in plasma zinc concentrations during the acute phase response. We carried out an observational cohort study in 689 children enrolled in a randomized trial of zinc supplementation during acute falciparum malaria in order to evaluate the relation between plasma zinc concentration and the acute phase response. Plasma zinc was measured by atomic absorption spectrophotometry. On admission, 70% of all subjects had low plasma zinc (<9.2 μmol/L). Multivariate analysis of predictors of admission plasma zinc showed that admission C-reactive protein (CRP), parasite density, and study site were the most important predictors. Predictors of changes in plasma zinc from admission to 72 h included baseline CRP, change in CRP, treatment group, study site, and baseline zinc concentration. In children with acute malaria infection, baseline plasma zinc concentrations were very low and were inversely correlated with CRP (r = -0.24, P < 0.0001) and the degree of parasitemia (r = -0.19, P < 0.0001). Even when CRP and time were taken into account, zinc supplementation increased plasma zinc concentration from admission to 72 h. When available, plasma zinc concentrations should be interpreted with concurrent measures of the acute phase response such as CRP. In children whose age, diet, and/or nutritional status place them at risk of zinc deficiency, those with low plasma zinc levels should be supplemented with oral zinc and followed for clinical and/or biochemical response. © 2005 American Society for Nutritional Sciences.
Authors & Co-Authors
Duggan, Christopher P.
United States, Boston
Boston Children's Hospital
United States, Boston
Harvard T.h. Chan School of Public Health
MacLeod, William Bruce
United States, Boston
School of Public Health
Krebs, Nancy F.
United States, Aurora
University of Colorado Anschutz Medical Campus
Westcott, Jamie E.
United States, Aurora
University of Colorado Anschutz Medical Campus
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Premji, Zulfiqarali G.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Mwanakasale, Victor
Zambia, Ndola
Tropical Diseases Research Centre
Simon, Jonathon L.
United States, Boston
School of Public Health
Yeboah-Antwi, Kojo
United States, Boston
School of Public Health
Ghana, Accra
Malaria Consortium
Hamer, Davidson Howes
United States, Boston
School of Public Health
United States, Medford
Tufts University
Statistics
Citations: 62
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1093/jn/135.4.802
ISSN:
00223166
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative