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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evidence of multiple introductions of HIV-1 subtype C in Angola
Infection, Genetics and Evolution, Volume 12, No. 7, Year 2012
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Description
HIV-1 subtype C is the most prevalent group M clade in southern Africa and some eastern African countries. Subtype C is also the most frequent subtype in Angola (southwestern Africa), with an estimated prevalence of 10-20%. In order to better understand the origin of the HIV-1 subtype C strains circulating in Angola, 31 subtype C pol sequences of Angolan origin were compared with 1950 subtype C pol sequences sampled in other African countries. Phylogenetic analyses reveal that the Angolan subtype C sequences were distributed in 16 different lineages that were widely dispersed among other African strains. Ten subtype C Angolan lineages were composed by only one sequence, while the remaining six clades contain between two and seven sequences. Bayesian phylogeographic analysis indicates that most Angolan clades probably originated in different southern African countries with the exception of one lineage that most likely originated in Burundi. Evolutionary analysis suggests that those Angolan subtype C clades composed by ≥2 sequences were introduced into the country between the late 1970s and the mid 2000s. The median estimated time frame for the origin of those Angolan lineages coincides with periods of positive migration influx in Angola that were preceded by phases of negative migratory outflow. These results demonstrate that the Angolan subtype C epidemic resulted from multiple introductions of subtype C viruses mainly imported from southern African countries over the last 30. years, some of which have been locally disseminated establishing several autochthonous transmission networks. This study also suggests that population mobility between Angola and southern African countries during civil war (1974-2002) may have played a key role in the emergence of the Angolan subtype C epidemic. © 2012 Elsevier B.V.
Authors & Co-Authors
Afonso, Joana Morais
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Angola, Luanda
University Agostinho Neto
Morgado, Mariza Gonçalves
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Bello, Gonzalo
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Statistics
Citations: 13
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.meegid.2012.05.005
ISSN:
15671348
e-ISSN:
15677257
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Angola
Burundi