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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene
Human Immunology, Volume 65, No. 7, Year 2004
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Description
Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. DNA from 190 patients with T1D and their families and 96 control individuals were genotyped for CTLA4 exon 1 polymorphism and human leukocyte antigen (HLA)-DQB1*0201 and*0302 haplotypes by polymerase chain reaction (PCR) amplification-restriction enzyme analysis and PCR amplification that used sequence-specific primers, respectively. Patients were nonobese and <26 years old. The CTLA4 G allele was found to be more frequently present in patients with T1D (32.4%) as compared with its frequency in control individuals (24.5%). The GG genotype was also significantly higher among patients (12.6%) than in controls (4.2%). χ 2 analysis and family-based association studies were performed and suggested the association of CTLA4 exon 1 G polymorphism with T1D (p = 0.0229). Furthermore, in HLA-DQB1*0201-positive patients with T1D, the GG and AA genotypes were higher and lower, respectively, than those found in control individuals. This study suggests that CTLA4 is a candidate susceptibility gene for T1D. © American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.
Authors & Co-Authors
Zalloua, Pierre A.
United States, Boston
Harvard T.h. Chan School of Public Health
Lebanon, Beirut
American University of Beirut
AbchÉE, Antoine B.
Lebanon, Beirut
American University of Beirut
Shbaklo, Hadia
Lebanon, Hazmieh
Chronic Care Center, Hazmieh
Zreik, Tony G.
Lebanon, Beirut
American University of Beirut
Terwedow, H.
United States, Boston
Harvard T.h. Chan School of Public Health
Halaby, G.
Lebanon, Hazmieh
Chronic Care Center, Hazmieh
Azar, Sami T.
Lebanon, Beirut
American University of Beirut
Lebanon, Hazmieh
Chronic Care Center, Hazmieh
Lebanon, Beirut
American University of Beirut Medical Center
Statistics
Citations: 57
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.humimm.2004.04.007
ISSN:
01988859
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study