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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A genome-wide screen for nicotine dependence susceptibility loci
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Volume 141, No. 4, Year 2006
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Description
Genome-wide model free linkage analysis was conducted for nicotine dependence and tobacco use phenotypes in 607 members of 158 nuclear families consisting of at least two ever smokers (100 or more cigarettes smoked in lifetime). DNA from whole blood was genotyped for 739 autosomal microsatellite polymorphisms with an average inter-marker distance of 4.6 cM. A peak LOD score of 2.7 was observed on chromosome 6 for scores for the Fagerström Test for Nicotine Dependence. Exploratory analyses were conducted to determine whether sequence variation at other loci affected other measures of dependence or tobacco use. Four additional loci with LOD scores of 2.7 or more were associated with alternative measures of nicotine dependence, one with current frequency of use, and one with smoking cessation. Several of the corresponding support intervals were near putative loci reported previously (on chromosomes 6, 7, and 8) while others appear to be novel (on chromosomes 5, 16, and 19). © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Swan, Gerald E.
United States, Menlo Park
Sri International
Wilhelmsen, Kirk C.
United States, San Francisco
University of California, San Francisco
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Chapel Hill
Unc School of Medicine
Amos, Christopher I.
United States, Houston
The University of Texas Md Anderson Cancer Center
Feiler, Heidi S.
United States, Berkeley
Lawrence Berkeley National Laboratory
Benowitz, Neal L.
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 54
Authors: 5
Affiliations: 8
Identifiers
Doi:
10.1002/ajmg.b.30315
ISSN:
1552485X
Research Areas
Cancer
Genetics And Genomics
Substance Abuse
Study Design
Exploratory Study