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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism
Metabolism: Clinical and Experimental, Volume 57, No. 9, Year 2008
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Description
Members of the cell death-inducing DFF45-like effector (CIDE) gene family have been shown to regulate lipid metabolism. In this article, we report that the third member of the human CIDE family, CIDEC, is down-regulated in response to a reduced caloric intake. The down-regulation was demonstrated by microarray and real-time polymerase chain reaction analysis of subcutaneous adipose tissue in 2 independent studies on obese patients undergoing treatment with a very low calorie diet. By analysis of CIDEC expression in 65 human tissues, we conclude that human CIDEC is predominantly expressed in subcutaneous adipocytes. Together, these observations led us to investigate the effect of decreased CIDEC expression in cultured 3T3-L1 adipocytes. Small interfering RNA-mediated knockdown of CIDEC resulted in an increased basal release of nonesterified fatty acids, decreased responsiveness to adrenergic stimulation of lipolysis, and increased oxidation of endogenous fatty acids. Thus, we suggest that CIDEC is a regulator of adipocyte lipid metabolism and may be important for the adipocyte to adapt to changes in energy availability. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Magnusson, Björn
Sweden, Gothenburg
Sahlgrenska Akademin
Gummesson, Anders
Sweden, Gothenburg
Sahlgrenska Akademin
Sweden, Gothenburg
Wallenberglaboratoriet
Glad, Camilla A.M.
Sweden, Gothenburg
Sahlgrenska Akademin
Goedecke, Julia H.
South Africa, Cape Town
Faculty of Health Sciences
Jernås, Margareta
Sweden, Gothenburg
Sahlgrenska Akademin
Lystig, Theodore C.
Sweden, Gothenburg
Sahlgrenska Akademin
Sweden, Sodertalje
Astrazeneca Sweden
Carlsson, Björn
Sweden, Gothenburg
Sahlgrenska Akademin
Sweden, Sodertalje
Astrazeneca Sweden
Fagerberg, Björn
Sweden, Gothenburg
Wallenberglaboratoriet
Sweden, Gothenburg
Sahlgrenska Akademin
Carlsson, Lena M.S.
Sweden, Gothenburg
Sahlgrenska Akademin
Svensson, Per Arne
Sweden, Gothenburg
Sahlgrenska Akademin
Statistics
Citations: 55
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/j.metabol.2008.04.028
ISSN:
00260495
Research Areas
Genetics And Genomics