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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Design and evaluation of controlled-release niosomes and discomes for naltrexone hydrochloride ocular delivery
Journal of Pharmaceutical Sciences, Volume 100, No. 5, Year 2011
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Description
This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and stearyl amine (STA)] and surfactants [poly-24-oxyethylene cholesteryl ether (C24) and sodium cholate (CH)] were investigated as bilayer membrane additives and prepared using four different methods. A 5-fold increase in NTX entrapment efficiency (EE%) was achieved with 2%-5% mol/mol additives. Differential scanning calorimetry thermograms revealed that the additives completely abolished gel/liquid transition suggesting that the bilayer membranes could accommodate the additives. The volume diameters D (4, 3) of the prepared niosomes were significantly [p < 0.05, analysis of variance (ANOVA)] dependent on the additive used. D (4,3) values of F-C24 and F-CH were 22.41 ± 1.40 and 5.37 ± 1.40 μm, respectively. F-S60, F-DCP, and F-CH shapes were typical spherical, whereas F-C24 was oval giant niosomes (discomes). In vitro drug release parameters showed that the prepared niosomes significantly (p < 0.01, ANOVA) controlled NTX release rate and extent. Ex vivo transcorneal permeation studies conducted using excised cow corneas showed that niosomes were capable of controlling NTX permeation and enhance its corneal permeability. The prepared niosomal formulations were found practically nonirritant when applied onto the surface of a 10-day-old hen's chorioallantoic membrane. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association.
Authors & Co-Authors
Abdelkader, Hamdy
New Zealand, Auckland
Faculty of Medical and Health Sciences
Egypt, Minya
Faculty of Pharmacy
Ismail, Sayed
Egypt, Asyut
Faculty of Pharmacy
Kamal, Amal
Egypt, Minya
Faculty of Pharmacy
Alany, Raid Ghassan
New Zealand, Auckland
Faculty of Medical and Health Sciences
United Kingdom, Kingston Upon Thames
Kingston University
Statistics
Citations: 141
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1002/jps.22422
ISSN:
00223549
e-ISSN:
15206017