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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Antibiotics susceptibility patterns of uropathogenic bacteria: a cross-sectional analytic study at Kanifing General Hospital, The Gambia
BMC Infectious Diseases, Volume 23, No. 1, Article 723, Year 2023
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Description
Background: Antimicrobial resistance poses a public health threat for the treatment of community-acquired urinary tract infections. This study determined the susceptibility patterns of uropathogens and associated risk factors among outpatients diagnosed with urinary tract infections at the Kanifing General Hospital in the Gambia. Methods: A cross-sectional analytic study was conducted among patients with suspected urinary tract infections at Kanifing General Hospital from March to May 2021. Data on socio-demographic and other risk factors were collected from the study participants using a structured pre-tested questionnaire. Mid-stream urine samples were collected, and bacteria identification and antimicrobial susceptibility testing done using standard microbiological methods. Descriptive and inferential statistical analysis were done to determine factors associated with urinary tract infection at 95% confidence level and a p -value < 0.05. Results: A total of 422 patients were enrolled with 82.5% (348/422) being females. The prevalence of community acquired urinary tract infection was 12.8% (54/422). Escherichia coli was the most prevalent isolate (74.1%, 40/54), followed by Klebsiella spp (8.5%, 10/54). Antimicrobial resistance was highest for Ampicillin (87.0%, 47/54), Trimethoprim/Sulfamethoxazole (77.8%, 42/54) and Tetracycline (75.9%, 41/54). Uropathogens sensitivity was 77.8% (42/54) for Nitrofurantoin and 75.9% (41/54) for Ceftazidime. Being female (aOR 5.90 95% CI = 1.48–23.67), previous history of urinary tract infection (aOR 2.34, 95% CI = 1.06–5.14), use of unprescribed antibiotics (aOR 2.0, 95% CI = 1.05–3.62) and having no formal education (aOR 8.02, 95% CI = 1.04–62.0) were significant factors associated for having uropathogenic bacterial infection. Conclusion: E. coli was the most prevalent uropathogen isolated. Ciprofloxacin, Nitrofurantoin and Ceftazidime were the most sensitive antibiotics. Routine surveillance of susceptibility of uropathogenic bacteria would be helpful to update clinicians on the choice of antibiotics. © 2023, BioMed Central Ltd., part of Springer Nature.
Authors & Co-Authors
Kebbeh, Abou
Ghana, Accra
University of Ghana
Gambia, Banjul
Ministry of Health
Dsane-Aidoo, Paul Henry
Switzerland, Geneva
Organisation Mondiale de la Santé
Fofana, Nuha
Ghana, Accra
University of Ghana
Ameme, Donne Kofi
Ghana, Accra
University of Ghana
Sanyang, Abdoulie M.
Gambia, Banjul
Ministry of Health
Darboe, Saffiatou
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sanneh, Bakary
Gambia, Banjul
Ministry of Health
Kenu, Ernest
Ghana, Accra
University of Ghana
Anto, Francis R.
Ghana, Accra
University of Ghana
Statistics
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/s12879-023-08373-y
ISSN:
14712334
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Gambia
Participants Gender
Female