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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Efficiency of inactivated vaccines against heartwater in Burkina Faso: Impact of Ehrlichia ruminantium genetic diversity
Vaccine, Volume 28, No. 29, Year 2010
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Description
In order to identify the appropriate strains to use in vaccination trials against heartwater in Burkina Faso, the protective effect of Gardel and Welgevonden strains was assessed against local strains on sheep vaccinated by infection-and-treatment method: Gardel protected significantly against Burkina Faso strains tested (survival rate 59% for immunised sheep vs 13% for control sheep) while Welgevonden did not (survival rate 45% for immunised sheep vs 25% for control sheep). The efficacy of the ISA50 inactivated vaccine, produced under industrial process, was evaluated in sheep during field challenges in two successive years. During year 1, there was a limited protective effect of the Gardel vaccine with 65% of survival rate for the vaccinated group compared to 49% for the control group (N = 153, p = 0.053). During year 2, the vaccine containing Gardel and a local strain gave an increased protective effect compared to the first trial: 72% of the vaccinated animals survived compared to 47% of the naïve animals (N = 173, p < 0.001). There was an important genetic diversity of strains in the field with detection of 11 different map1 genotypes in brains from control and vaccinated sheep post mortem. Map1 genotyping of strains detected in brains from control sheep showed that genotype distribution varied according to time and study areas, which could explain the difference in efficacy of the vaccine. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Adakal, Hassane
Burkina Faso, Bobo-dioulasso
Centre International de Recherche-developpement Sur Lelevage en Zone Subhumide, Bobo-dioulasso
Stachurski, Frédéric
Burkina Faso, Bobo-dioulasso
Centre International de Recherche-developpement Sur Lelevage en Zone Subhumide, Bobo-dioulasso
France, Montpellier
Inrae's Occitanie-montpellier Centre
Konkobo, Maurice
Burkina Faso, Bobo-dioulasso
Centre International de Recherche-developpement Sur Lelevage en Zone Subhumide, Bobo-dioulasso
Zoungrana, Sébastien
Burkina Faso, Bobo-dioulasso
Centre International de Recherche-developpement Sur Lelevage en Zone Subhumide, Bobo-dioulasso
Meyer, Damien F.
France, Paris
Cirad
Pinarello, Valérie
France, Paris
Cirad
Aprelon, Rosalie
France, Paris
Cirad
Marcelino, Isabel
Portugal, Oeiras
Instituto de Biologia Experimental e Tecnológica
Alves, Paula M.
Portugal, Oeiras
Instituto de Biologia Experimental e Tecnológica
Martinez, Dominique
France, Montpellier
Inrae's Occitanie-montpellier Centre
France, Paris
Cirad
Lefrancois, T.
France, Paris
Cirad
Vachiéry, Nathalie
France, Paris
Cirad
Statistics
Citations: 31
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2010.04.087
ISSN:
0264410X
Research Areas
Genetics And Genomics
Study Design
Randomised Control Trial
Study Locations
Burkina Faso