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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High rate of hepatitis C virus infection and predominance of genotype 4 among elderly inhabitants of a remote village of the rain forest of South Cameroon
Journal of Medical Virology, Volume 71, No. 2, Year 2003
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Description
To determine the prevalence of hepatitis C virus (HCV) infection and genotype distribution in a rural isolated area of Central Africa, plasma of 409 Bantous (mean age, 32 years; range, 2-78 years) living in a remote village of the rain forest of Southern Cameroon was screened for anti-HCV antibodies. HCV seropositive samples were also subjected to qualitative detection of viral RNA. HCV antibodies were detected in 70 (17.1%) individuals, 48 (68.8%) of whom had detectable viremia. The seroprevalence did not differ by gender (P=0.37), but increased significantly with age (P<0.05), with a strong increase in the oldest age groups. Indeed, nearly one-half (48%) of the adults >50 years old were HCV seropositive. The characterization of the viral genotypes indicated that most of the HCV strains were of genotype 4 (76%), while genotype 2 (16%), and 1 (8%) were marginally represented. The results suggest a cohort effect with an old, possibly iatrogenic, group exposure rather than a continuous exposure. A more in-depth population-based epidemiological study is needed to address this issue further. © 2003 Wiley-Liss, Inc.
Authors & Co-Authors
Njouom, Richard
Cameroon, Yaounde
Centre Pasteur du Cameroun
France, Toulouse
Hôpital Purpan
Pasquier, Christophe J.M.
France, Toulouse
Hôpital Purpan
Ayouba, Ahidjo
Cameroon, Yaounde
Centre Pasteur du Cameroun
Gessain, Antoine
France, Paris
Epidémiologie et Physiopathologie Des Virus Oncogènes
Froment, Alain
France, Orleans
Ird Centre D'orleans
Mfoupouendoun, Jermie
Cameroon, Yaounde
Centre Pasteur du Cameroun
Pouillot, R.
Cameroon, Yaounde
Centre Pasteur du Cameroun
Dubois, Martine
France, Toulouse
Hôpital Purpan
Sandres-Sauné, Karine
France, Toulouse
Hôpital Purpan
Thonnon, Jocelyn
Cameroon, Yaounde
Centre Pasteur du Cameroun
Izopet, Jacques
France, Toulouse
Hôpital Purpan
Nerrienet, Eric
Cameroon, Yaounde
Centre Pasteur du Cameroun
Statistics
Citations: 64
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.10473
ISSN:
01466615
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Qualitative
Study Locations
Cameroon