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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients
British Journal of Surgery, Volume 110, No. 12, Year 2023
Notification
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Description
Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2: 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding. © The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd.
Authors & Co-Authors
Hannink, Gerjon
Netherlands, Nijmegen
Radboud Universiteit
Wolthuis, Albert M.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
de Lacy, Francisco Borja
Spain, Barcelona
Hospital Clinic Barcelona
Frasson, Matteo
Spain, Valencia
Hospital Universitari I Politècnic la fe
Denost, Quentin D.
Unknown Affiliation
Panís, Yves H.
Unknown Affiliation
Rutegård, Martin
Sweden, Umea
Umeå Universitet
Hompes, R. J.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Cancer Center Amsterdam
Rosman, Camiel
Netherlands, Nijmegen
Radboud Universiteit
Tanis, Pieter Job
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Cancer Center Amsterdam
Netherlands, Rotterdam
Erasmus Mc
De Wilt, Johannes Hans W.Hans
Netherlands, Nijmegen
Radboud Universiteit
D'Hoore, André J.L.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Lacy, Antonio María
Spain, Barcelona
Hospital Clinic Barcelona
Frontali, A.
France, Clichy
Hôpital Beaujon
Berney, Christophe Roger
Australia, Bankstown
Bankstown-lidcombe Hospital
Kroon, Hidde M.
Australia, Adelaide
Royal Adelaide Hospital
Dudi-Venkata, Nagendra N.
Australia, Adelaide
Royal Adelaide Hospital
Slavchev, M.
Bulgaria, Plovdiv
Medical University of Plovdiv
Belev, Nikolay
Bulgaria, Plovdiv
Medical University of Plovdiv
Atanasov, Boyko Tchavdarov
Bulgaria, Plovdiv
Medical University of Plovdiv
Maslyankov, Svilen
Bulgaria, Sofia
University Hospital Alexandrovska
Karamanliev, Martin P.
Bulgaria, Pleven
Medical University - Pleven
Tonchev, Pencho
Bulgaria, Pleven
Medical University - Pleven
Aigner, Felix
Unknown Affiliation
Buchs, Nicolas Christian
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Ris, Frédéric
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Toso, Christian
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Škrovina, Matěj
Unknown Affiliation
Pratschke, Johann
Germany, Berlin
Freie Universität Berlin
Perez, Daniel R.
Unknown Affiliation
Iversen, Lene Hjerrild
Denmark, Aarhus
Aarhus Universitetshospital
Teras, Jüri
Estonia, Tallinn
North Estonia Medical Centre
Monib, Fatma Ahmed
Egypt, Asyut
Assiut University
Ali, Ahmad K.
Egypt, Asyut
Assiut University
Khedr, Gehan Abd Elatti
Egypt, Alexandria
Alexandria University Hospitals
Abdelaal, Ahmed Samir A.
Egypt, Alexandria
Alexandria University Hospitals
Ewedah, Moataz
Egypt, Alexandria
Alexandria University Hospitals
ElShennawy, Eslam Mohamed
Unknown Affiliation
Sanchez-Guillen, Luís
Spain, Elche
Hospital General Universitario de Elche
Mendoza-Moreno, Fernando
Spain, Alcala de Henares
Hospital Universitario Príncipe de Asturias
Matias-García, Belén
Spain, Alcala de Henares
Hospital Universitario Príncipe de Asturias
Quiroga-Valcárcel, Ana
Spain, Alcala de Henares
Hospital Universitario Príncipe de Asturias
Blas, Juan Luis
Spain, Zaragoza
Hospital Royo Villanova
Estaire-Gómez, Mercedes
Spain, Ciudad Real
Hospital General de Ciudad Real
Pellino, Gianluca
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Espin-Basany, Eloy
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
De’ Angelis, Nicola
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Lauka, Lelde
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Ramsay, George
United Kingdom, Aberdeen
Nhs Grampian
Hamid, Hytham K.S.
United Kingdom, Canterbury
East Kent Hospitals University Nhs Foundation Trust
de Simone, Belinda D.
United Kingdom, Canterbury
East Kent Hospitals University Nhs Foundation Trust
Chaudhri, Sanjay
United Kingdom, Leicester
Leicester General Hospital
Singh, Nirbhaibir
United Kingdom, Wolverhampton
The Royal Wolverhampton Nhs Trust
Manatakis, Dimitrios K.
Greece, Athens
Athens Naval Hospital
Tasis, Nikolaos P.
Greece, Athens
Athens Naval Hospital
Charalabopoulos, Alexandros
Greece, Athens
Laikon General Hospital
Schizas, Dimitrios N.
Greece, Athens
Laikon General Hospital
Balalis, Dimitrios
Unknown Affiliation
Korkolis, Dimitrios P.
Unknown Affiliation
Chrysos, Emmanuel
Greece, Heraklion
Heraklion University Hospital
Kelly, Michael Eamon
Ireland, Dublin
Trinity College Dublin
Neary, Peter Mark
Ireland, Waterford
University Hospital Waterford
Ryan, Jessica M.
Ireland, Waterford
University Hospital Waterford
Hammoodi, Hayder A.
Iraq, Najaf
Al-sadder Teaching Hospital
Calabro, Marcello
Italy, Pinerolo
Edoardo Agnelli Hospital
Fabbri, Nicolò
Italy, Ferrara
University of Ferrara
Pesce, Antonio
Italy, Ferrara
University of Ferrara
Roscio, Francesco Pietro Maria
Unknown Affiliation
Persiani, Roberto
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Biondi, Alberto
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Spinelli, Antonino
Italy, Pieve Emanuele
Humanitas University
Sacchi, Matteo M.
Italy, Pieve Emanuele
Humanitas University
Garulli, Gianluca
Unknown Affiliation
Delrio, Paolo
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Carbone, Fabio
Italy, Naples
Istituto Nazionale Tumori Irccs - Fondazione g Pascale, Napoli
Pirozzolo, Giovanni
Italy, Mestre
Ospedale Dell'angelo
Recordare, Alfonso Giovanni
Italy, Mestre
Ospedale Dell'angelo
Corbellini, Carlo
Unknown Affiliation
Montroni, Isacco
Italy, Ravenna
Ospedale S. Maria Delle Croci
Galleano, R.
Italy, Pietra Ligure
Azienda Ospedaliera Ospedale Santa Corona
Tamini, Nicolò
Italy, Monza
Azienda Ospedaliera San Gerardo Monza
Catena, Fausto
Italy, Parma
Azienda Ospedaliero-universitaria Di Parma
Annicchiarico, Alfredo
Italy, Parma
Azienda Ospedaliero-universitaria Di Parma
Perrone, Gennaro
Italy, Parma
Azienda Ospedaliero-universitaria Di Parma
Grossi, Ugo
Unknown Affiliation
Zanus, Giacomo
Unknown Affiliation
Soriero, Domenico
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Gallo, Gaetano
Italy, Catanzaro
Università Degli Studi Magna Graecia Di Catanzaro
Pucciarelli, Salvatore
Italy, Padua
Azienda Ospedale Università Padova
Di Saverio, S.
Italy, Varese
Azienda Ospedaliera Ospedale Di Circolo e Fondazione Macchi Di Varese
Lapolla, Pierfrancesco
Italy, Rome
Sapienza Università Di Roma
Brachini, Gioia
Italy, Rome
Sapienza Università Di Roma
Mingoli, Andrea
Italy, Rome
Sapienza Università Di Roma
Siragusa, Leandro
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Dé Manzoni, Giovanni D.
Italy, Verona
Università Degli Studi Di Verona
Rabadi, Alexander D.
Jordan, Amman
The University of Jordan
El-Muhtaseb, Mohammad Sami H.
Jordan, Amman
The University of Jordan
Žilinskas, Justas
Lithuania, Kaunas
Lietuvos Sveikatos Mokslų Universitetas
Poškus, Tomas
Lithuania, Vilnius
Vilniaus Universitetas
Abdulwahed, Eman
Libya, Tripoli
Tripoli Central Hospital
Alshareea, Entisar Ahmed Ali
Libya, Tripoli
Tripoli Central Hospital
Elhadi, Muhammed K.
Libya, Tripoli
University of Tripoli
Msherghi, Ahmed
Libya, Tripoli
University of Tripoli
Majbar, Anass Mohammed
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Souadka, Amine
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Benkabbou, Amine
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Mohsine, Raouf
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Zakaria, Andee Dzulkarnaen
Malaysia, Kubang Kerian
Universiti Sains Malaysia, Health Campus
Ibrahim, Aini Fahriza
Malaysia, Kota Samarahan
Universiti Malaysia Sarawak
Verdaasdonk, Emiel G.G.
Netherlands, 's-hertogenbosch
Jeroen Bosch Hospital
Consten, Esther Catharina Josephina
Netherlands, Groningen
Universitair Medisch Centrum Groningen
den Boer, Frank C.
Netherlands, Zaandam
Ziekenhuis de Heel, Zaandam
Boerma, Evert Jan G.
Unknown Affiliation
Azevedo, Constança M.
Portugal, Covilha
Centro Hospitalar Universitário Cova da Beira
Negoi, Ionut
Romania, Bucharest
Universitatea de Medicina si Farmacie Carol Davila Din Bucuresti
Ciubotaru, Cezar I.
Romania, Bucharest
Universitatea de Medicina si Farmacie Carol Davila Din Bucuresti
Negoita, Valentina Madalina
Unknown Affiliation
Dimofte, Mihail Gabriel
Unknown Affiliation
Garmanova, Tatiana
Russian Federation, Moscow
Lomonosov Moscow State University
Drozdov, Evgeniy S.
Russian Federation, Tomsk
Siberian State Medical University
Buchwald, Pamela L.
Sweden, Lund
Skånes Universitetssjukhus
Lindqvist, Ebba K.
Sweden, Lund
Skånes Universitetssjukhus
Zazo, Aya
Syrian Arab Republic, Aleppo
University of Aleppo
Ayoub, Kusay
Syrian Arab Republic, Aleppo
University of Aleppo
Hamdan, Alaa
Syrian Arab Republic, Latakia
Université Tichrine
Sebai, Amine
Tunisia, Tunis
Hôpital la Rabta
Haddad, Anis
Tunisia, Tunis
Hôpital la Rabta
Maghrebi, Houcine
Tunisia, Tunis
Hôpital la Rabta
Kacem, Montasser Jameleddine
Tunisia, Tunis
Hôpital la Rabta
Sivrikoz, Emre
Turkey, Istanbul
Bahçeşehir Üniversitesi
Çolak, Elif F.
Turkey, Samsun
Samsun University
Demirli Atlcl, Semra
Turkey, Istanbul
University of Health Sciences
Monson, John R.T.
Unknown Affiliation
Boutall, Adam B.T.
South Africa, Cape Town
University of Cape Town
Herman, Ayesiga M.
South Africa, Cape Town
University of Cape Town
Warden, Claire
South Africa, Cape Town
University of Cape Town
Forgan, Timothy
South Africa, Tygerberg
Tygerberg Hospital
Mia, Imraan
South Africa, Tygerberg
Tygerberg Hospital
Statistics
Authors: 138
Affiliations: 179
Identifiers
Doi:
10.1093/bjs/znad311
ISSN:
00071323
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative