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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus [ALS2] on chromosome 2q33
Neurogenetics, Volume 2, No. 1, Year 1998
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Description
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative neuromuscular disease that shows familial, autosomal dominant inheritance in 10%-15% of cases. Previous genetic analysis of one large family linked a recessive form of familial ALS (FALS-AR type 3) to the chromosome 2q33-35 region. Using additional polymorphic markers, we have narrowed the size of the linked region to approximately 1.7 cM by linkage and haplotype analysis. We have also established a yeast artificial chromosome contig across the locus that covers an approximate physical distance of 3 million bases. Based on this contig, genes and expressed sequences that map near the 2q33 region have been examined to determine whether they are located within this ALS2 candidate locus. Five identified genes and 34 expressed sequence tags map within the region defined by crossover analysis and merit further consideration as candidate genes for this disease. © Springer-Verlag 1998.
Authors & Co-Authors
Hosler, Betsy A.
United States, Boston
Massachusetts General Hospital
Sapp, Peter C.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Massachusetts Institute of Technology
Berger, Ralph
United States, Denver
Eleanor Roosevelt Institute
O'Neill, Gilmore
United States, Boston
Massachusetts General Hospital
Bejaoui, Khemissa
United States, Boston
Massachusetts General Hospital
Ben-Hamida, Mongi G.M.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Hentati, F. F.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Chin, Wendy
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Massachusetts Institute of Technology
McKenna-Yasek, Diane M.
United States, Boston
Massachusetts General Hospital
Haines, Jonathan L.
United States, Nashville
Vanderbilt University Medical Center
Patterson, David
United States, Denver
Eleanor Roosevelt Institute
United States, Aurora
University of Colorado Anschutz Medical Campus
Horvitz, H. Robert
United States, Cambridge
Massachusetts Institute of Technology
Brown, Robert D.
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 29
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1007/s100480050049
ISSN:
13646745
Research Areas
Genetics And Genomics