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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
TLR9 polymorphisms are associated with altered IFN-γ levels in children with cerebral malaria
American Journal of Tropical Medicine and Hygiene, Volume 82, No. 4, Year 2010
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Description
Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at -1237 and G allele at 1174 were strongly linked, and among children with CM, those with the C allele at -1237 or the G allele at 1174 had higher levels of IFN-γ than those without these alleles (P = 0.03 and 0.008, respectively). The TLR9 SNPs were not associated with altered IFN-γ levels in children with UM or altered TNF-α levels in either group. We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2844552/bin/SD2.pdf
Authors & Co-Authors
Sam-Agudu, Nadia Adjoa
United States, Minneapolis
Center for Global Pediatrics
Greene, Jennifer A.
United States, Cleveland
Case School of Medicine
Opoka, Robert Opika
Uganda, Kampala
Mulago Hospital
Kazura, James W.
United States, Cleveland
Case School of Medicine
Boivin, Michael Joseph
Unknown Affiliation
Zimmerman, Peter A.
United States, Cleveland
Case School of Medicine
Riedesel, Melissa A.
United States, Minneapolis
Center for Global Pediatrics
Bergemann, Tracy L.
United States, Minneapolis
School of Public Health
Schimmenti, Lisa
United States, Minneapolis
Genetics
John, Chandy Chiramukhathu
United States, Minneapolis
Center for Global Pediatrics
Statistics
Citations: 59
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2010.09-0467
ISSN:
00029637
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health