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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-Term Outcomes With Transcatheter Aortic Valve Replacement in Women Compared With Men: Evidence From a Meta-Analysis
JACC: Cardiovascular Interventions, Volume 11, No. 1, Year 2018
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Description
Objectives This study sought to examine long-term outcomes with transcatheter aortic valve replacement (TAVR) in women versus men. Background TAVR is commonly performed in women. Previous studies have shown conflicting results with respect to sex differences in outcomes with TAVR. In addition, short-term outcomes have primarily been reported. Methods Electronic search was performed until March 2017 for studies reporting outcomes with TAVR in women versus men. Random effects DerSimonian-Laird risk ratios were calculated. Outcomes included all-cause mortality and major cardiovascular events at short- (30 days) and long-term (>1 year) follow-up. Results Seventeen studies (8 TAVR registries; 47,188 patients; 49.4% women) were analyzed. Women were older but exhibited fewer comorbidities. At 30 days, women had more bleeding (p < 0.001), vascular complications (p < 0.001), and stroke/transient ischemic attack (p = 0.02), without difference in all-cause (p = 0.19) or cardiovascular mortality (p = 0.91) compared with men. However, female sex was associated with lower all-cause mortality at 1 year (risk ratio: 0.85; 95% confidence interval: 0.79 to 0.91; p < 0.001), and longest available follow-up (mean 3.28 ± 1.04 years; risk ratio: 0.86; 95% confidence interval: 0.81 to 0.92; p < 0.001), potentially caused by less moderate/severe aortic insufficiency (p = 0.001), and lower cardiovascular mortality (p = 0.009). The female survival advantage remained consistent across multiple secondary analyses. The risk of stroke, moderate/severe aortic insufficiency, and all-cause mortality seemed to vary based on the type of valve used; however, without significant subgroup interactions. Conclusions Despite a higher upfront risk of complications, women derive a better long-term survival after TAVR compared with men. © 2018 American College of Cardiology Foundation
Authors & Co-Authors
Saad, Marwan
United States, Little Rock
University of Arkansas for Medical Sciences
Nairooz, Ramez S.
United States, Los Angeles
University of Southern California
Pothineni, Naga Venkata Krishna Chand
United States, Little Rock
University of Arkansas for Medical Sciences
Kovelamudi, Swathi
United States, Little Rock
University of Arkansas for Medical Sciences
Abdel-Wahab, Mohamed Kader
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Bangalore, Sripal
United States, New York
Nyu Grossman School of Medicine
Kleiman, Neal S.
United States, Houston
Houston Methodist
Abbott, Jinnette Dawn
United States, Providence
Brown University
Statistics
Citations: 91
Authors: 8
Affiliations: 9
Identifiers
Doi:
10.1016/j.jcin.2017.08.015
ISSN:
19368798
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Systematic review
Participants Gender
Male
Female