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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictors of pregnancy in microbicide trials
Contraception, Volume 83, No. 5, Year 2011
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Description
Background: High pregnancy rates undermine the conduct and interpretation of HIV prevention trials. We performed this analysis to identify baseline participant characteristics associated with increased risk of pregnancy in recent vaginal microbicide trials. Study Design: We analyzed the data from four recently completed Phase III trials of candidate microbicides for prevention of HIV infection. Cox proportional hazard models, stratified by site nested within study, were used to determine the baseline factors that predict pregnancy. Six thousand seven hundred forty-eight women contributed data for this analysis. Results: Pregnancies were detected in a total of 1826 (27.1%) women. The hazard of pregnancy was higher for women who had a history of pregnancy, were living with a man or reported more sexual acts not protected by condoms in the week prior to enrollment. The risk of pregnancy was lower in older participants; in women with more years of education; in women who reported more sexual partners at baseline interview; in women who reported using intrauterine contraception, implants, sterilization or injectables and in women who reported use of a condom during their last act of vaginal intercourse. Conclusions: Our data suggest that current use or acceptance of intrauterine contraception, implants, sterilization or injectables is the most effective approach to reduce pregnancy rates and might be a useful eligibility criterion in future HIV prevention trials. © 2011 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Halpern, Vera
United States, Durham
Fhi 360
Lie, Che Chin
United States, Durham
Fhi 360
Feldblum, Paul J.
United States, Durham
Fhi 360
van Damme, Lut
United States, Durham
Fhi 360
United States, Arlington
Conrad
Weaver, Mark A.
United States, Durham
Fhi 360
Mauck, Christine K.
United States, Arlington
Conrad
Guédou, Fernand Aimé
Canada, Quebec
Chu de Québec-université Laval
Mirembe, Florence Maureen
Uganda, Kampala
Makerere University
Govinden, Roshini
South Africa, Tygerberg
South African Medical Research Council
Obunge, Orikomaba K.
Nigeria, Port Harcourt
University of Port Harcourt
Ogunsola, F. T.
Nigeria, Lagos
University of Lagos
Statistics
Citations: 18
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.contraception.2010.08.018
ISSN:
00107824
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female