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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats
Environmental Toxicology and Pharmacology, Volume 22, No. 1, Year 2006
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Description
The effect of Coriander pretreatment on gastric mucosal injuries caused by NaCl, NaOH, ethanol, indomethacin and pylorus ligation accumulated gastric acid secretions was investigated in rats. Pretreatment at oral doses of 250 and 500 mg/kg, body weight was found to provide a dose-dependent protection against the (i) ulcerogenic effects of different necrotizing agents; (ii) ethanol-induced histopathological lesions; (iii) pylorus ligated accumulation of gastric acid secretions and ethanol related decrease of Nonprotein Sulfhydryl groups (NP-SH). Results obtained on the study of gastric mucus and indomethacin-induced ulcers demonstrated that the gastro protective activity of Coriander might not be mediated by gastric mucus and/or endogenous stimulation of prostaglandins. The protective effect against ethanol-induced damage of the gastric tissue might be related to the free-radical scavenging property of different antioxidant constituents (linanool, flavonoids, coumarins, catechins, terpenes and polyphenolic compounds) present in Coriander. The inhibition of ulcers might be due to the formation of a protective layer of either one or more than one of these compounds by hydrophobic interactions. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Al-Mofleh, Ibraheem Abdulkarim
Saudi Arabia, Riyadh
King Saud University
Alhaider, Abdulqader A.
Saudi Arabia, Riyadh
King Saud University
Mossa, Jaber S.
Saudi Arabia, Riyadh
College of Pharmacy
Al-Sohaibani, Mohammed Omar
Saudi Arabia, Riyadh
King Saud University
Rafatullah, Syed
Saudi Arabia, Riyadh
College of Pharmacy
Qureshi, Shoeb
Saudi Arabia, Riyadh
College of Pharmacy
Statistics
Citations: 86
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.etap.2005.12.002
ISSN:
13826689
Research Areas
Health System And Policy
Violence And Injury