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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Survival following massive overdose of adrenergic blocking agents (acebutolol and labetalol)
European Heart Journal, Volume 4, No. 5, Year 1983
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Description
Massive overdosage of adrenergic blocking drugs is associated with severe morbidity and a high mortality rate. We report the case of a 24-year-old medical intern who ingested 9.6 g acebutolol, 7.2 g labetalol and 0.625 g trimipramine in an attempted suicide Blood samples drawn on admission were shown to contain markedly elevated plasma levels of acebutolol and its major metabolite and of labetalol. The patient was deeply comatose on admission. The heart rate was 60 min-1 (sinus rhythm) and the blood pressure was clinically unrecordable. Atropine, isoproterenol and dopamine initially had no effect on either heart rate or blood pressure. Only following the administration of inordinately large doses of isoproterenol and dopamine, together with glucagon was a clinical response obtained. The patient remained haemodynamically dependent on dopamine for 12 h and isoproterenol for 65 h. The total dose of isoproterenol administered was 260 mg, two thirds of this during the first 12 h. The patient left hospital well after 7 days but was readmitted after 26 days because of intestinal obstruction due to ischemic bowel necrosis. © 1983 The European Society of Cardiology.
Authors & Co-Authors
Lewis, Michael Ian
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Kallenbach, Jeremy M.
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Germond, C.
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Zaltzman, Mathew
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Müller, F. O.
South Africa, Bloemfontein
University of the Free State
Steyn, Josef M.
Unknown Affiliation
Zwi, Saul
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Statistics
Citations: 32
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1093/oxfordjournals.eurheartj.a061469
ISSN:
0195668X
Research Areas
Health System And Policy
Mental Health
Noncommunicable Diseases