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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IL-12Rβ2 is essential for the development of experimental cerebral malaria
Journal of Immunology, Volume 188, No. 4, Year 2012
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Description
A Th1 response is required for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The role of pro-Th1 IL-12 in malaria is complex and controversial. In this study, we addressed the role of IL-12Rβ2 in ECM development. C57BL/6 mice deficient for IL-12Rβ2, IL-12p40, or IL-12p35 were analyzed for ECM development after blood-stage PbA infection in terms of ischemia and blood flow by noninvasive magnetic resonance imaging and angiography, T cell recruitment, and gene expression. Without IL-12Rβ2, no neurologic sign of ECM developed upon PbA infection. Although wildtype mice developed distinct brain microvascular pathology, ECM-resistant, IL-12Rβ2-deficient mice showed unaltered cerebral microcirculation and the absence of ischemia after PbA infection. In contrast, mice deficient for IL-12p40 or IL-12p35 were sensitive to ECM development. The resistance of IL-12Rβ2-deficient mice to ECM correlated with reduced recruitment of activated T cells and impaired overexpression of lymphotoxin-α, TNF-α, and IFN-γ in the brain after PbA infection. Therefore, IL-12Rβ2 signaling is essential for ECM development but independent from IL-12p40 and IL-12p35. We document a novel link between IL-12Rβ2 and lymphotoxin-α, TNF-α, and IFN-γ expression, key cytokines for ECM pathogenesis. Copyright©2012 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Fauconnier, Mathilde
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Palomo, Jennifer
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Bourigault, Marie Laure
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Meme, Sandra
France, Orleans
Cbm Centre de Biophysique Moléculaire
Szeremeta, Frédéric
France, Orleans
Cbm Centre de Biophysique Moléculaire
Beloeil, Jean Claude
France, Orleans
Cbm Centre de Biophysique Moléculaire
Danneels, Adeline
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Charron, Sabine
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Rihet, Pascal
France, Marseille
Technologie Avancée Pour le Génome et la Clinique
France, Marseille
Aix Marseille Université
Ryffel, Bernhard
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
Quesniaux, Valérie F.J.
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Statistics
Citations: 38
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.4049/jimmunol.1101978
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Genetics And Genomics
Infectious Diseases