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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome
PLoS ONE, Volume 6, No. 3, Article e14741, Year 2011
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Description
Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases. © 2011 Ochola et al.
Authors & Co-Authors
Ochola, Lucy B.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Siddondo, Bethsheba R.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Ocholla, Harold
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Nkya, Siana
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Kimani, Eva N.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Williams, Thomas Neil
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
University of Oxford
Makale, Johnstone O.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Liljander, Anne
Sweden, Stockholm
Karolinska Institutet
Urban, Britta Christina
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Bull, Peter C.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Nuffield Department of Medicine
Szestak, Tadge
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Marsh, Kevin
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Nuffield Department of Medicine
Craig, Alister Gordon
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 137
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0014741
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases