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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Multiple novel astrovirus species in human stool
Journal of General Virology, Volume 90, No. 12, Year 2009
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Description
Diarrhoea remains a significant cause of morbidity and mortality in developing countries where numerous cases remain without identified aetiology. Astroviruses are a recently identified cause of animal gastroenteritis which currently includes two species suspected of causing human diarrhoea. Using pan-astrovirus RT-PCR, we analysed human stool samples from different continents for astrovirus-related RNA sequences. We identified variants of the two known human astrovirus species plus, based on genetic distance criteria, three novel astrovirus species all distantly related to mink and ovine astroviruses, which we provisionally named HMOAstV species A-C. The complete genome of species A displayed all the conserved characteristics of mammalian astroviruses. Each of the now three groups of astroviruses found in human stool (HAstV, AstV-MLB and HMOAstV) were more closely related to animal astroviruses than to each other, indicating that human astroviruses may periodically emerge from zoonotic transmissions. Based on the pathogenic impact of their closest phylogenetic relatives in animals, further investigations of the role of HMOAstV, so far detected in Nigeria, Nepal and Pakistan, in human gastroenteritis are warranted. © 2009 SGM.
Authors & Co-Authors
Kapoor, Amit
United States, San Francisco
Ucsf School of Medicine
Li, Linlin
United States, San Francisco
Ucsf School of Medicine
Victoria, Joseph
United States, San Francisco
Ucsf School of Medicine
Oderinde, Bamidele Soji
Nigeria, Maiduguri
University of Maiduguri
Mason, Carl Jeffries
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Pandey, Prativa
Nepal, Kathmandu
Ciwec Travel Medicine Centre Nepal
Zaidi, Syed Sohail Zahoor
Pakistan, Islamabad
National Institute of Health Pakistan
Delwart, E. L.
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 224
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1099/vir.0.014449-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Nigeria