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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays
BMC Infectious Diseases, Volume 11, Article 264, Year 2011
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Description
Background: There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-g Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).Methods: A cross sectional study was conducted to assess the prevalence of and risk factors for a positive diagnostic test for LTBI, using tuberculin skin test (TST) and IGRAs among HIV-discordant couples in Zambia.Results: A total of 596 subjects (298 couples) were enrolled. Median CD4 count among HIV positive persons was 388 cells/μl, (range 51-1330). HIV negative persons were more likely than their HIV positive partner, to have a positive diagnostic test for LTBI with TST (203 vs 128), QFT (171 vs 109) and TSPOT (156 vs. 109). On multivariate analysis, HIV negative status was an independent predictor for a positive QFT (OR = 2.22, 95% CI 1.42- 3.46) and TSPOT (OR = 1.79, 95% CI 1.16-2.77). Among HIV positive subjects a CD4 count ≥ 388 cells/μl was associated with a positive TST (OR = 1.76 95% CI 1.10-2.82) and QFT (OR = 1.71 95% CI 1.06-2.77) but not TSPOT (OR = 1.20 95% CI 0.74-1.94).Conclusions: Persons with HIV had significantly fewer positive diagnostic tests for LTBI with TST, QFT and TSPOT. Persons with a CD4 count < 388 cells/μl were less likely to have a positive TST or QFT, but not less likely to have a positive TSPOT. TSPOT may perform better than TST or QFT in HIV positive individuals. © 2011 Talati et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Talati, Naasha J.
United States, Philadelphia
University of Pennsylvania
González Díaz, Esteban
Mexico, Guadalajara
Hospital Civil de Guadalajara
Mutemba, Charles
Zambia, Lusaka
Zambia-emory Hiv Research Project
Wendt, Joyanna
United States, Atlanta
Emory University
Kilembe, William
Zambia, Lusaka
Zambia-emory Hiv Research Project
Mwananyanda, Lawrence M.
Zambia, Lusaka
Zambia-emory Hiv Research Project
Chomba, Elwyn Nachanya
Zambia, Lusaka
Zambia-emory Hiv Research Project
Allen, Susan A.
Zambia, Lusaka
Zambia-emory Hiv Research Project
United States, Atlanta
Rollins School of Public Health
Del Rio, Carlos D.
United States, Atlanta
Emory University
United States, Atlanta
Rollins School of Public Health
Blumberg, Henry Michael
United States, Atlanta
Emory University
United States, Atlanta
Rollins School of Public Health
Statistics
Citations: 20
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-11-264
e-ISSN:
14712334
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Zambia