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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Geographically Structured Populations of Cryptococcus neoformans Variety grubii in Asia Correlate with HIV Status and Show a Clonal Population Structure
PLoS ONE, Volume 8, No. 9, Article e72222, Year 2013
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Description
Cryptococcosis is an important fungal disease in Asia with an estimated 140,000 new infections annually the majority of which occurs in patients suffering from HIV/AIDS. Cryptococcus neoformans variety grubii (serotype A) is the major causative agent of this disease. In the present study, multilocus sequence typing (MLST) using the ISHAM MLST consensus scheme for the C. neoformans/C. gattii species complex was used to analyse nucleotide polymorphisms among 476 isolates of this pathogen obtained from 8 Asian countries. Population genetic analysis showed that the Asian C. neoformans var. grubii population shows limited genetic diversity and demonstrates a largely clonal mode of reproduction when compared with the global MLST dataset. HIV-status, sequence types and geography were found to be confounded. However, a correlation between sequence types and isolates from HIV-negative patients was observed among the Asian isolates. Observations of high gene flow between the Middle Eastern and the Southeastern Asian populations suggest that immigrant workers in the Middle East were originally infected in Southeastern Asia. © 2013 Khayhan et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3760895/bin/pone.0072222.s001.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3760895/bin/pone.0072222.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3760895/bin/pone.0072222.s003.doc
Authors & Co-Authors
Khayhan, Kantarawee
Unknown Affiliation
Hagen, Ferry
Unknown Affiliation
Pan, Weihua
Unknown Affiliation
Simwami, Sitali
Unknown Affiliation
Fisher, Matthew C.
Unknown Affiliation
Wahyuningsih, Retno
Unknown Affiliation
Chakrabarti, Arunaloke K.
Unknown Affiliation
Chowdhary, Anuradha K.
Unknown Affiliation
Ikeda, Reiko
Unknown Affiliation
Taj-Aldeen, S.
Unknown Affiliation
Khan, Ziauddin
Unknown Affiliation
Ip, Margaret P.Y.
Unknown Affiliation
Imran, Darma
Unknown Affiliation
Sjam, Ridhawati
Unknown Affiliation
Sriburee, Pojana
Unknown Affiliation
Liao, Wangqing
Unknown Affiliation
Chaicumpar, Kunyaluk
Unknown Affiliation
Vuddhakul, Varaporn
Unknown Affiliation
Meyer, Wieland
Unknown Affiliation
Trilles, Luciana
Unknown Affiliation
van Iersel, Leo J.J.
Unknown Affiliation
Meis, Jacques F.
Unknown Affiliation
Klaassen, Corné H.W.
Unknown Affiliation
Boekhout, Teun
Unknown Affiliation
Statistics
Citations: 90
Authors: 24
Affiliations: 23
Identifiers
Doi:
10.1371/journal.pone.0072222
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study