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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Essential oils from Moroccan plants as potential chemosensitisers restoring antibiotic activity in resistant Gram-negative bacteria
International Journal of Antimicrobial Agents, Volume 38, No. 4, Year 2011
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Description
Bacterial drug resistance is a worrying public health problem. Antibiotic efflux is a major non-specific resistance mechanism used by bacteria, and efflux pumps are involved in the low-level susceptibility of various important Gram-negative pathogens. Use of molecules that can block bacterial pumps is an attractive strategy, but several studies report only partial efficacy owing to limits of these molecules (stability, selectivity, bioavailability, toxicity, etc.). The objective of this study was to search for natural sources of molecules able to inhibit efflux pump systems of resistant Gram-negative bacteria (Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Salmonella enterica serotype Typhimurium and Pseudomonas aeruginosa). The results indicate that the studied essential oils exhibit interesting activity against the tested bacteria. This activity was significantly enhanced in the presence of an efflux pump inhibitor such as phenylalanine arginyl β-naphthylamide (PAβN). The role of lipopolysaccharide (LPS) structure in the effect of essential oils was also reported in Salmonella LPS deep-rough mutants. In addition, essential oils of Thymus maroccanus and Thymus broussonetii, used at a low concentration (a fraction of the minimum inhibitory concentration), are able to significantly increase chloramphenicol susceptibility of several resistant isolates. These results demonstrate that these essential oils can alter efflux pump activity and may be attractive candidates to develop new drugs for chemosensitising multidrug-resistant strains to clinically used antibiotics. © 2011 Elsevier B.V. and the International Society of Chemotherapy.
Authors & Co-Authors
Fadli, Mariam
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Morocco, Marakech
Université Cadi Ayyad
Chevalier, Jacqueline
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Saad, Asmaa
Morocco, Marakech
Université Cadi Ayyad
Mezrioui, Noureddine
Morocco, Marakech
Université Cadi Ayyad
Hassani, Lahcen
Morocco, Marakech
Université Cadi Ayyad
PAGES, Jean Marie
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Statistics
Citations: 87
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijantimicag.2011.05.005
ISSN:
09248579
e-ISSN:
18727913
Research Areas
Cancer
Infectious Diseases