Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Co-trimoxazole Prophylaxis, Asymptomatic Malaria Parasitemia, and Infectious Morbidity in Human Immunodeficiency Virus-Exposed, Uninfected Infants in Malawi: The BAN Study
Clinical Infectious Diseases, Volume 65, No. 4, Year 2017
Notification
URL copied to clipboard!
Description
Background Human immunodeficiency virus (HIV)-exposed infants are disproportionately at risk of morbidity and mortality compared with their HIV-unexposed counterparts. The role of co-trimoxazole preventive therapy (CPT) in reducing leading causes of infectious morbidity is unclear. Methods We used data from the Breastfeeding, Antiretrovirals and Nutrition (BAN) clinical trial (conducted 2004-2010, Malawi) to assess the association of (1) CPT and (2) asymptomatic malaria parasitemia with respiratory and diarrheal morbidity in infants. In June 2006, all HIV-exposed infants in BAN began receiving CPT (240 mg) from 6 to 36 weeks of age, or until weaning occurred and HIV infection was ruled out. All HIV-exposed, uninfected infants (HEIs) at 8 weeks of age (n = 1984) were included when CPT was the exposure. A subset of HEIs (n = 471) were tested for malarial parasitemia using dried blood spots from 12, 24, and 36 weeks of age. Cox proportional hazards models for recurrent gap-time data were used to examine the association of time-varying exposures on morbidity. Results CPT was associated with a 36% reduction in respiratory morbidity (hazard ratio [HR], 0.64 [95% confidence interval {CI},.60-.69]) and a 41% reduction in diarrheal morbidity (HR, 0.59 [95% CI,.54-.65]). Having asymptomatic malaria parasitemia was associated with a 40% increase in respiratory morbidity (HR, 1.40 [95% CI, 1.13-1.74]) and a 50% increase in diarrheal morbidity (HR, 1.50 [95% CI, 1.09-2.06]), after adjusting for CPT. Conclusions CPT may have an important role to play in reducing the leading global causes of morbidity and mortality in the growing population of HEIs in malaria-endemic resource-limited settings. © Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Authors & Co-Authors
Davis, Nicole L.
United States, Atlanta
Centers for Disease Control and Prevention
Wiener, Jeffrey B.
United States, Atlanta
Centers for Disease Control and Prevention
Juliano, Jonathan J.
United States, Chapel Hill
Unc School of Medicine
Adair, Linda S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Chasela, Charles S.
South Africa, Johannesburg
University of the Witwatersrand
Kayira, Dumbani
Malawi, Lilongwe
Unc Project-malawi
Hudgens, Michael G.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
van der Horst, Charles Michael
United States, Chapel Hill
Unc School of Medicine
Jamieson, Denise J.
United States, Atlanta
Centers for Disease Control and Prevention
Kourtis, Athena P.
United States, Atlanta
Centers for Disease Control and Prevention
Ahmed, Yusuf I.
Unknown Affiliation
Ait-Khaled, Mounir
Unknown Affiliation
Albrecht, Sandra S.
Unknown Affiliation
Bangdiwala, Shrikant I.
Unknown Affiliation
Bayer, Ronald
Unknown Affiliation
Bentley, Margaret E.
Unknown Affiliation
Bramson, Brian
Unknown Affiliation
Bobrow, Emily A.
Unknown Affiliation
Boyle, Nicola
Unknown Affiliation
Butera, Salvatore T.
Unknown Affiliation
Chavula, Charity
Unknown Affiliation
Chimerang'Ambe, Joseph
Unknown Affiliation
Chigwenembe, Maggie
Unknown Affiliation
Chikasema, Maria
Unknown Affiliation
Chikhungu, Norah
Unknown Affiliation
Chilongozi, David A.T.
Unknown Affiliation
Chiudzu, Grace
Unknown Affiliation
Chome, Lenesi
Unknown Affiliation
Cole, Anne
Unknown Affiliation
Corbett, Amanda H.
Unknown Affiliation
Corneli, Amy L.
Unknown Affiliation
Dow, Annae
Unknown Affiliation
Duerr, Ann C.
Unknown Affiliation
Eliya, Henry
Unknown Affiliation
Ellington, Sascha R.
Unknown Affiliation
Eron, Joseph J.
Unknown Affiliation
Farr, Sherry L.
Unknown Affiliation
Owens Ferguson, Yvonne
Unknown Affiliation
Fiscus, Susan A.
Unknown Affiliation
Flax, Valerie L.
Unknown Affiliation
Fokar, Ali
Unknown Affiliation
Galvin, Shannon R.
Unknown Affiliation
Guay, Laura A.
Unknown Affiliation
Heilig, Charles M.
Unknown Affiliation
Hoffman, Irving F.
Unknown Affiliation
Hooten, Elizabeth Gerken
Unknown Affiliation
Hosseinipour, Mina C.
Unknown Affiliation
Hurst, Stacy
Unknown Affiliation
Hyde, Lisa
Unknown Affiliation
Joaki, George R.F.
Unknown Affiliation
Jones, David
Unknown Affiliation
Jordan-Bell, Elizabeth
Unknown Affiliation
Kacheche, Zebrone K.
Unknown Affiliation
Kamanga, Esmie
Unknown Affiliation
Kamanga, Gift
Unknown Affiliation
Kampani, Coxcilly
Unknown Affiliation
Kamthunzi, Portia
Unknown Affiliation
Kamwendo, Deborah D.
Unknown Affiliation
Kanyama, Cecilia
Unknown Affiliation
Kashuba, Angela D.M.
Unknown Affiliation
Kathyola, Damson D.
Unknown Affiliation
Kazembe, Peter Nicholas
Unknown Affiliation
King, Caroline C.
Unknown Affiliation
Knight, Rodney J.
Unknown Affiliation
Krysiak, Robert G.
Unknown Affiliation
Kumwenda, Jacob
Unknown Affiliation
Lee, Hana
Unknown Affiliation
Loeliger, Edde
Unknown Affiliation
Long, Dustin M.
Unknown Affiliation
Luhanga, Misheck Richard
Unknown Affiliation
Madhlopa, Victor
Unknown Affiliation
Majawa, Maganizo
Unknown Affiliation
Maida, Alice
Unknown Affiliation
Marcus, Cheryl J.
Unknown Affiliation
Martinson, Francis
Unknown Affiliation
Thoofer, Navdeep K.
Unknown Affiliation
Matiki, Chrissie
Unknown Affiliation
Mayers, Douglas L.
Unknown Affiliation
Mayuni, Isabel
Unknown Affiliation
McDonough, Marita D.
Unknown Affiliation
Meme, Joyce
Unknown Affiliation
Merry, Concepta
Unknown Affiliation
Mita, Khama
Unknown Affiliation
Mkomawanthu, Chimwemwe
Unknown Affiliation
Mndala, Gertrude
Unknown Affiliation
Mndala, Ibrahim
Unknown Affiliation
Moses, Agnes
Unknown Affiliation
Msika, Albans
Unknown Affiliation
Msungama, Wezi
Unknown Affiliation
Mtimuni, Beatrice M.
Unknown Affiliation
Muita, Jane
Unknown Affiliation
Mumba, Noel
Unknown Affiliation
Musis, Bonface
Unknown Affiliation
Mwansambo, Charles C.V.
Unknown Affiliation
Mwapasa, Gerald
Unknown Affiliation
Nkhoma, Jacqueline R.
Unknown Affiliation
Parker, Megan E.
Unknown Affiliation
Pendame, Richard B.
Unknown Affiliation
Piwoz, Ellen G.
Unknown Affiliation
Raines, Byron N.
Unknown Affiliation
Ramdas, Zane
Unknown Affiliation
Ryan, Máirín A.A.
Unknown Affiliation
Sanne, Ian M.
Unknown Affiliation
Sellers, Christopher J.
Unknown Affiliation
Shugars, Diane C.
Unknown Affiliation
Sichali, Dorothy S.
Unknown Affiliation
Snowden, Wendy B.
Unknown Affiliation
Soko, Alice
Unknown Affiliation
Spensley, Allison
Unknown Affiliation
Steens, Jean Marc
Unknown Affiliation
Tegha, Gerald L.
Unknown Affiliation
Tembo, Martin
Unknown Affiliation
Thomas, Roshan
Unknown Affiliation
Tien, Hsiaochuan
Unknown Affiliation
Tohill, Beth Carlton
Unknown Affiliation
Waalberg, Esther
Unknown Affiliation
Widen, Elizabeth Marie
Unknown Affiliation
Wilfert, Catherine M.
Unknown Affiliation
Wiyo, Patricia
Unknown Affiliation
Zimba, Chifundo Colleta
Unknown Affiliation
Statistics
Citations: 6
Authors: 120
Affiliations: 5
Identifiers
Doi:
10.1093/cid/cix367
ISSN:
10584838
Research Areas
Environmental
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Malawi