Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification
Diabetologia, Volume 57, No. 8, Year 2014
Notification
URL copied to clipboard!
Description
Aims/hypothesis: Diabetic nephropathy is a major diabetic complication, and diabetes is the leading cause of end-stage renal disease (ESRD). Family studies suggest a hereditary component for diabetic nephropathy. However, only a few genes have been associated with diabetic nephropathy or ESRD in diabetic patients. Our aim was to detect novel genetic variants associated with diabetic nephropathy and ESRD. Methods: We exploited a novel algorithm, 'Bag of Naive Bayes', whose marker selection strategy is complementary to that of conventional genome-wide association models based on univariate association tests. The analysis was performed on a genome-wide association study of 3,464 patients with type 1 diabetes from the Finnish Diabetic Nephropathy (FinnDiane) Study and subsequently replicated with 4,263 type 1 diabetes patients from the Steno Diabetes Centre, the All Ireland-Warren 3-Genetics of Kidneys in Diabetes UK collection (UK-Republic of Ireland) and the Genetics of Kidneys in Diabetes US Study (GoKinD US). Results: Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study. An association between ESRD and rs17709344, tagging the previously identified rs12437854 and located between the RGMA and MCTP2 genes, was replicated in independent case-control cohorts. rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p<0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno. Conclusions/interpretation: This study supports the previously identified findings on the RGMA/MCTP2 region and suggests novel susceptibility loci for ESRD. This highlights the importance of applying complementary statistical methods to detect novel genetic variants in diabetic nephropathy and, in general, in complex diseases. © 2014 Springer-Verlag.
Authors & Co-Authors
Sambo, Francesco
Italy, Padua
Università Degli Studi Di Padova
Malovini, Alberto
Italy, Pavia
Università Degli Studi Di Pavia
Italy, Pavia
Istituti Clinici Scientifici Maugeri Spa – sb
Sandholm, Niina
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Finland, Espoo
Aalto University
Stavarachi, Monica
Finland, Helsinki
Folkhälsan Institute of Genetics
Romania, Bucharest
Universitatea Din Bucuresti
Forsblom, Carol M.
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Mak̈inen, Ville Petteri
United States, Los Angeles
University of California, Los Angeles
Australia, Adelaide
South Australian Health and Medical Research Institute
Harjutsalo, Valma
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Lithovius, Raija
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Gordin, Daniel
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Parkkonen, Maija
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Saraheimo, Markku
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Thorn, Lena M.
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Tolonen, Nina E.
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Wad́en, Johan
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
He, Bing
Sweden, Stockholm
Karolinska Institutet
Österholm, Anne May
Sweden, Stockholm
Karolinska Institutet
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Austria, Krems an Der Donau
Donau-universität Krems
Saudi Arabia, Jeddah
King Abdulaziz University
Lajer, Maria Stenkil
Denmark, Herlev
Steno Diabetes Center Copenhagen
Salem, Rany M.
United States, Boston
Harvard Medical School
United States, Cambridge
Broad Institute
United States, Boston
Boston Children's Hospital
McKnight, Amy Jayne
United Kingdom, Belfast
Queen's University Belfast
Tarnow, Lise
Denmark, Aarhus
Fakultetet Health
Denmark, Hillerod
Nordsjællands Hospital - Hillerød
Panduru, Nicolae Mircea
Finland, Helsinki
Folkhälsan Institute of Genetics
Romania, Bucharest
Universitatea de Medicina si Farmacie Carol Davila Din Bucuresti
Barbarini, Nicola
Italy, Pavia
Università Degli Studi Di Pavia
Di Camillo, Barbara
Italy, Padua
Università Degli Studi Di Padova
Toffolo, Gianna Maria
Italy, Padua
Università Degli Studi Di Padova
Tryggvason, Karl
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Bellazzi, Riccardo
Italy, Pavia
Università Degli Studi Di Pavia
Cobelli, Claudio
Italy, Padua
Università Degli Studi Di Padova
Groop, Per Henrik
Finland, Helsinki
Folkhälsan Institute of Genetics
Finland, Helsinki
Helsinki University Hospital
Australia, Melbourne
Baker Heart and Diabetes Institute
Statistics
Citations: 29
Authors: 29
Affiliations: 22
Identifiers
Doi:
10.1007/s00125-014-3256-2
ISSN:
0012186X
e-ISSN:
14320428
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study