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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder
Neuroscience Letters, Volume 420, No. 1, Year 2007
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Description
There is evidence that major psychiatric discords such as schizophrenia (SZ) and bipolar disorder (BD) are associated with dysregulation of synaptic plasticity with downstream alterations of neurotrophins. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system (CNS), and performs many biological functions such as promoting the survival, differentiation, and plasticity of neurons. Variants in the BDNF gene increase the risk of SZ and bipolar disorder. Chronic administration of drugs used to treat SZ and BD, such as lithium, valproate, quetiapine, clozapine, and olanzapine, increases BDNF expression in rat brain. To examine serum BDNF, three groups of chronically medicated DSM-IV SZ patients, on treatment with clozapine (n = 27), typical (n = 14), and other atypical antipsychotics (n = 19), 30 euthymic BD patients, and 26 healthy control had 5 ml blood samples collected by venipuncture. Serum BDNF levels were significantly higher in SZ patients (p < 0.001) when compared to either controls or euthymic BD patients. Increased BDNF in SZ patients might be related to the course of illness or to treatment variables. Prospective studies are warranted. © 2007 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Gama, Clarissa Severino
Brazil, Porto Alegre
Hospital de Clinicas de Porto Alegre
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Kunz, Maurício
Brazil, Porto Alegre
Hospital de Clinicas de Porto Alegre
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Berk, Michael
Australia, Geelong
Barwon Health
Australia, Melbourne
Orygen Research Centre
Australia, Melbourne
The Florey
Kapczinski, Flávio Pereira
Brazil, Porto Alegre
Hospital de Clinicas de Porto Alegre
Brazil, Porto Alegre
Universidade Federal do Rio Grande do Sul
Statistics
Citations: 159
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.1016/j.neulet.2007.04.001
ISSN:
03043940
Research Areas
Genetics And Genomics
Mental Health
Study Design
Cohort Study