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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
npj Breast Cancer, Volume 5, No. 1, Article 38, Year 2019
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Description
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors. © 2019, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6825205/bin/41523_2019_127_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6825205/bin/41523_2019_127_MOESM2_ESM.pdf
Authors & Co-Authors
Figlioli, Gisella
Italy, Milan
Fondazione Ifom Istituto Firc Di Oncologia Molecolare
Bogliolo, Massimo
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Catucci, Irene
Italy, Milan
Fondazione Ifom Istituto Firc Di Oncologia Molecolare
Caleca, L.
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Lasheras, Sandra Viz
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Pujol, Roser M.
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Kiiski, Johanna I.
Finland, Helsinki
Helsinki University Hospital
Muranen, Taru A.
Finland, Helsinki
Helsinki University Hospital
Barnes, Daniel R.
United Kingdom, Cambridge
University of Cambridge
Dennis, Joe G.
United Kingdom, Cambridge
University of Cambridge
Michailidou, Kyriaki
United Kingdom, Cambridge
University of Cambridge
Cyprus, Nicosia
Cyprus Institute of Neurology and Genetics
Bolla, Manjeet K.
United Kingdom, Cambridge
University of Cambridge
Leslie, Goska
United Kingdom, Cambridge
University of Cambridge
Aalfs, Cora M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Balleine, Rosemary L.
Australia, Sydney
Westmead Hospital
Baxter, Robert C.
Australia, Sydney
The University of Sydney
Braye, Stephen
Australia, Newcastle
John Hunter Hospital
Carpenter, Jane E.
Australia, Parramatta
The Westmead Institute for Medical Research
Dahlstrom, Jane E.
Australia, Canberra
Canberra Hospital
Australia, Canberra
The Australian National University
Forbes, John F.
Australia, Waratah
Calvary Mater Newcastle
Lee, Cheok Soon
Australia, Penrith
Western Sydney University
Marsh, Deborah J.
Australia, Sydney
The University of Sydney
Australia, Sydney
Royal North Shore Hospital
Morey, Adrienne L.
Australia, Sydney
St. Vincent's Hospital Sydney
Pathmanathan, Nirmala
Australia, Sydney
Cancer Institute Nsw
Scott, Rodney J.
Australia, Newcastle
Hunter Medical Research Institute, Australia
Australia, Callaghan
The University of Newcastle, Australia
Australia, Newcastle
John Hunter Hospital
Simpson, Peter Thomas
Australia, Brisbane
The University of Queensland
Spigelman, Allan D.
Australia, Sydney
The Kinghorn Cancer Centre
Wilcken, Nicholas R.C.
Australia, Sydney
Westmead Hospital
Australia, Sydney
The University of Sydney
Yip, Desmond
Australia, Canberra
Canberra Hospital
Zeps, Nikolajs
Unknown Affiliation
Adank, Muriel A.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Adlard, Julian W.
United Kingdom, Leeds
Chapel Allerton Hospital
Agata, Simona
Italy, Padua
Istituto Oncologico Veneto Iov - Irccs
Cadoo, Karen A.
United States, New York
Memorial Sloan-kettering Cancer Center
Agnarsson, Bjarni Agnar
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Ahearn, Thomas U.
United States, Bethesda
National Institutes of Health Nih
Aittomäki, Kristiina A.U.
Finland, Helsinki
Helsinki University Hospital
Ambrosone, Christine B.
United States, Buffalo
Roswell Park Cancer Institute
Andrews, Lesley
Unknown Affiliation
Anton-Culver, Hoda
United States, Irvine
University of California, Irvine
Antonenkova, Natalia Nikolaevna
Belarus, Minsk
Research Institute of Oncology and Medical Radiology of the Ministry of Health of the Byelorussian Ssr
Arndt, Volker
Germany, Heidelberg
German Cancer Research Center
Arnold, Norbert K.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Aronson, Kristan J.
Canada, Kingston
Queen’s University
Arun, Banu K.
United States, Houston
The University of Texas Md Anderson Cancer Center
Asseryanis, Ella
Austria, Vienna
Medizinische Universität Wien
Auber, Bernd
Germany, Hannover
Hannover Medical School
Auvinen, P.
Finland, Kuopio
Kuopio University Hospital
Finland, Kuopio
Itä-suomen Yliopisto
Azzollini, Jacopo
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Balmaña, Judith
Spain, Barcelona
Vall D‘hebron Institut de Oncologia
Spain, Barcelona
Hospital Universitari Vall D'hebron
Barkardóttir, Rósa Björk
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Barrowdale, Daniel
United Kingdom, Cambridge
University of Cambridge
Barwell, Julian G.
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Beane-Freeman, Laura E.
United States, Bethesda
National Institutes of Health Nih
Beauparlant, Charles Joly
Canada, Quebec
Université Laval
Beckmann, Matthias Wilhelm
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Behrens, Sabine
Germany, Heidelberg
German Cancer Research Center
Benit́ez, Javier J.
Spain, Madrid
Centro Nacional de Investigaciones Oncológicas
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Berger, Raanan
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Bermisheva, Marina A.
Russian Federation, Moscow
Russian Academy of Sciences
Blanco, Amie M.
United States, San Francisco
University of California, San Francisco
Blomqvist, Carl Peter
Finland, Helsinki
Helsinki University Hospital
Sweden, Orebro
Universitetssjukhuset Örebro
Bogdanova, Natalia Valerijevna
Belarus, Minsk
Research Institute of Oncology and Medical Radiology of the Ministry of Health of the Byelorussian Ssr
Germany, Hannover
Hannover Medical School
Bojesen, Anders Bo
Denmark, Aarhus
Aarhus Universitetshospital
Bojesen, Stig Egil
Denmark, Copenhagen
Copenhagen University Hospital
Denmark, Copenhagen
Københavns Universitet
Bonanni, Bernardo
Italy, Milan
Istituto Europeo Di Oncologia
Borg, Åke
Sweden, Lund
Lunds Universitet
Brady, Angela F.
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Brauch, Hiltrud B.
Germany, Stuttgart
Dr. Margarete Fischer-bosch-institut Für Klinische Pharmakologie
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Heidelberg
German Cancer Research Center
Brenner, Hermann
Germany, Heidelberg
German Cancer Research Center
Brüning, Thomas A.
Germany, Bochum
Institut Für Prävention Und Arbeitsmedizin Der Deutschen Gesetzlichen Unfallversicherung
Burwinkel, Barbara
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Buys, Saundra S.
United States, Salt Lake City
Huntsman Cancer Institute
Caldés, Trinidad
Spain, Madrid
Centro de Investigación Biomédica en Red de Cáncer
Caliebe, Almuth
Germany, Kiel
Christian-albrechts-universität zu Kiel
Caligo, Maria Adelaide
Italy, Pisa
Azienda Ospedaliero Universitaria Pisana
Campa, Daniele
Germany, Heidelberg
German Cancer Research Center
Italy, Pisa
Università Di Pisa
Campbell, I. G. G.
Australia, Melbourne
Peter Maccallum Cancer Centre
Canzian, Federico
Germany, Heidelberg
German Cancer Research Center
Castelao, Jose Esteban
Spain, Vigo
Oncology and Genetics Unit
Chang-Claude, Jenny C.
Germany, Heidelberg
German Cancer Research Center
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
Claes, Kathleen B.M.
Belgium, Ghent
Universiteit Gent
Clarke, Christine L.
Australia, Parramatta
The Westmead Institute for Medical Research
Collavoli, Anita
Italy, Pisa
Università Di Pisa
Conner, Thomas A.
United States, Salt Lake City
Huntsman Cancer Institute
Cox, David G.
United Kingdom, London
Imperial College London
France, Paris
Inserm
Cybulski, Cezary
Poland, Szczecin
Pomeranian Medical University in Szczecin
Czene, Kamila
Sweden, Stockholm
Karolinska Institutet
Daly, Mary B.
United States, Philadelphia
Fox Chase Cancer Center
de la Hoya, Miguel
Spain, Madrid
Centro de Investigación Biomédica en Red de Cáncer
Devilée, Peter P.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Díez, Orland
Spain, Barcelona
Vall D‘hebron Institut de Oncologia
Spain, Barcelona
Hospital Universitari Vall D'hebron
Ding, Yuanchun
United States, Duarte
City of Hope National Med Center
Dite, Gillian S.
Australia, Melbourne
University of Melbourne
Ditsch, Nina
Germany, Munich
Ludwig-maximilians-universität München
Domchek, Susan M.
United States, Philadelphia
University of Pennsylvania
Dorfling, Cecilia M.
South Africa, Pretoria
University of Pretoria
Dos Santos Silva, Isabel M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Durda, Katarzyna M.
Poland, Szczecin
Pomeranian Medical University in Szczecin
Dwek, Miriam Victoria
United Kingdom, London
University of Westminster
Eccles, Diana M.
United Kingdom, Southampton
University of Southampton
Ekici, Arif Bülent
Unknown Affiliation
Eliassen, A. Heather
United States, Boston
Harvard Medical School
United States, Boston
Harvard T.h. Chan School of Public Health
Ellberg, Carolina
Sweden, Lund
Lunds Universitet
Eriksson, Mikael
Sweden, Stockholm
Karolinska Institutet
Evans, D. Gareth R.
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
United Kingdom, Manchester
Health Innovation Manchester
Fasching, Peter Andreas
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
United States, Los Angeles
University of California, Los Angeles
Figueroa, Jonine D.
United States, Bethesda
National Institutes of Health Nih
United Kingdom, Edinburgh
Edinburgh Medical School
United Kingdom, London
Cancer Research uk
Flyger, Henrik Lavlund
Denmark, Copenhagen
Copenhagen University Hospital
Foulkes, William D.
Canada, Montreal
Université Mcgill
Friebel, Tara M.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Dana-farber Cancer Institute
Friedman, Eitan A.
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Israel, Tel Aviv-yafo
Tel Aviv University
Gabrielson, Marike
Sweden, Stockholm
Karolinska Institutet
Gago-Dominguez, Manuela
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
United States, La Jolla
University of California, San Diego
Gapstur, Susan M.
United States, Kennesaw
American Cancer Society
Garber, Judy Ellen
United States, Boston
Dana-farber Cancer Institute
García-Closas, Montserrat
United States, Bethesda
National Institutes of Health Nih
García-Saénz, José Ángel
Spain, Madrid
Centro de Investigación Biomédica en Red de Cáncer
Gaudet, Mia M.
United States, Kennesaw
American Cancer Society
Gayther, Simon A.
United States, Los Angeles
Cedars-sinai Medical Center
Belotti, Muriel
France, Paris
Institut Curie
Buecher, Bruno
France, Paris
Institut Curie
Caputo, S. M.
France, Paris
Institut Curie
Mouret-Fourme, Emmanuelle
France, Paris
Institut Curie
Gauthier-Villars, Marion
France, Paris
Institut Curie
Golmard, Lisa
France, Paris
Institut Curie
de Pauw, Antoine
France, Paris
Institut Curie
Boutry-Kryza, Nadia
France, Lyon
Chu de Lyon
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Calender, Alain
France, Lyon
Chu de Lyon
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Giraud, Sophie S.
France, Lyon
Chu de Lyon
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Léoné, Meĺanie
France, Lyon
Chu de Lyon
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Bressac-De-Paillerets, Brigitte
France, Villejuif
Institut de Cancerologie Gustave Roussy
Caron, Olivier Md Msc
France, Villejuif
Institut de Cancerologie Gustave Roussy
Guillaud-Bataille, Marine
France, Villejuif
Institut de Cancerologie Gustave Roussy
Bignon, Yves Jean
France, Clermont-ferrand
Centre Jean Perrin
Uhrhammer, Nancy A.
France, Clermont-ferrand
Centre Jean Perrin
Bonadona, Valérie
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Lasset, Christine
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Berthet, Pascaline
France, Caen
Centre François Baclesse
Castéra, Laurent
France, Caen
Centre François Baclesse
Vaur, Dominique
France, Caen
Centre François Baclesse
Bourdon, Violaine
France, Marseille
Institut Paoli-calmettes
Noguès, Catherine
France, Marseille
Institut Paoli-calmettes
Noguchi, Testsuro
France, Marseille
Institut Paoli-calmettes
Popovici, Cornel
France, Marseille
Institut Paoli-calmettes
Remenieras, Audrey
France, Marseille
Institut Paoli-calmettes
Sobol, Hagay H.
France, Marseille
Institut Paoli-calmettes
Coupier, Isabelle
France, Montpellier
Hopital Arnaud de Villeneuve
Pujol, Pascal
France, Montpellier
Hopital Arnaud de Villeneuve
Révillion, Françoise
France, Lille
Centre Oscar Lambret
Muller, Danièle
France, Strasbourg
Centre Paul Strauss Centre Régional de Lutte Contre le Cancer de Strasbourg
Barouk-Simonet, Emmanuelle
France, Bordeaux
Institut Bergonie
Bonnet, Françoise
France, Bordeaux
Institut Bergonie
Longy, Michel
France, Bordeaux
Institut Bergonie
Sévenet, Nicolas
France, Bordeaux
Institut Bergonie
Gladieff, Laurence
France, Toulouse
Institut Claudius Regaud
Guimbaud, Rosine
France, Toulouse
Institut Claudius Regaud
Toulas, Christine
France, Toulouse
Institut Claudius Regaud
Dreyfus, Hélène
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
Faivre, Laurence Olivier
France, Dijon
Centre Hospitalier Universitaire Dijon Bourgogne
Lebrun, Marine
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Prieur, Fabienne
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Fert-Ferrer, Sandra
France, Chambery
Centre Hospitalier Chambéry
Mari, Véronique
France, Nice
Centre Antoine Lacassagne
Bézieau, Stéphane
France, Nantes
Chu de Nantes
Delnatte, Capucine D.
France, Nantes
Chu de Nantes
Mortemousque, Isabelle
France, Tours
Hopital Bretonneau
Colas, Chrystelle
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Coulet, Florence P.
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Soubrier, Florent
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Bronner, Myriam
France, Nancy
Chu de Nancy
Sokolowska, Joanna
France, Nancy
Chu de Nancy
Collonge-Rame, Marie Agnès
France, Besancon
Centre Hospitalier Universitaire de Besançon
Gesta, Paul H.
France, Poitiers
Centre Hospitalier Universitaire de Poitiers
Chiésa, Jean
France, Nimes
Hôpital Universitaire Carémeau
Manouvrier-Hanu, Sylvie
France, Lille
Chu Lille
Lejeune, Sophie
France, Lille
Chu Lille
Giles, Graham G.
Australia, Melbourne
University of Melbourne
Australia, East Melbourne
Cancer Council Victoria
Australia, Clayton
Monash University
Glendon, Gord
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Godwin, Andrew K.
United States, Kansas City
University of Kansas Medical Center
Goldberg, Mark S.
Canada, Montreal
Université Mcgill
Goldgar, David F.
United States, Salt Lake City
University of Utah School of Medicine
Guénel, Pascal
France, Gif-sur-yvette
Université Paris-saclay
Gutierrez Barrera, Angelica M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Haeberle, Lothar
Unknown Affiliation
Haiman, Christopher A.
United States, Los Angeles
University of Southern California
Håkansson, Niclas N.
Sweden, Stockholm
Karolinska Institutet
Hall, Per F.L.
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Södersjukhuset
Hamann, Ute
Germany, Heidelberg
German Cancer Research Center
Harrington, Patricia A.
United Kingdom, Cambridge
University of Cambridge
Hein, Alexander
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Heyworth, Jane Shirley
Australia, Perth
The University of Western Australia
Hillemanns, Peter
Germany, Hannover
Hannover Medical School
Hollestelle, Antoinette
Netherlands, Rotterdam
Erasmus Mc Cancer Institute
Hopper, John Llewelyn
Australia, Melbourne
University of Melbourne
Mhimbira, Francis Dean
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Howell, Anthony H.
United Kingdom, Manchester
The University of Manchester
Hu, Chunling
United States, Rochester
Mayo Clinic
Hulick, Peter J.
United States, Evanston
Northshore University Healthsystem
United States, Chicago
Pritzker School of Medicine
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
United Kingdom, Oxford
University of Oxford
Imyanitov, Evgeny N.
Russian Federation, Saint Petersburg
N.n. Petrov Research Institute of Oncology of the Ussr Ministry of Health
Aghmesheh, Morteza
Australia, Wollongong
Wollongong Hospital
Amor, D. John O.
Australia, Melbourne
Royal Children's Hospital, Melbourne
Buckley, Michael Francis
Australia, Sydney
Prince of Wales Hospital
Friedlander, M. L.
Australia, Sydney
Prince of Wales Hospital
Meiser, Bettina
Australia, Sydney
Prince of Wales Hospital
Tucker, Katherine M.
Australia, Sydney
Prince of Wales Hospital
Antill, Yoland C.
Australia, Melbourne
Peter Maccallum Cancer Centre
Dobrovic, Alexander N.
Australia, Melbourne
Peter Maccallum Cancer Centre
Fox, Stephen B.
Australia, Melbourne
Peter Maccallum Cancer Centre
Harris, Marion T.
Australia, Melbourne
Peter Maccallum Cancer Centre
Phillips, K. A.
Australia, Melbourne
Peter Maccallum Cancer Centre
Thorne, Heather J.
Australia, Melbourne
Peter Maccallum Cancer Centre
Bastick, Patricia A.
Australia, Sydney
St George Hospital
Beesley, Jonathan
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Hayward, Nicholas K.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Spurdle, Amanda B.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Walker, Logan C.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Beilby, John P.
Australia, Perth
Queen Elizabeth Ii Medical Centre Trust
Saunders, Christobel Mary
Australia, Perth
Queen Elizabeth Ii Medical Centre Trust
Gaff, Clara Louise
Australia, Melbourne
Royal Melbourne Hospital
Lindeman, Geoffrey J.
Australia, Melbourne
Royal Melbourne Hospital
Pachter, Nicholas S.
Australia, Melbourne
Royal Melbourne Hospital
Scott, Clare L.
Australia, Melbourne
Royal Melbourne Hospital
Winship, Ingrid M.
Australia, Melbourne
Royal Melbourne Hospital
French, Juliet D.
Australia, Brisbane
The University of Queensland
Butow, Phyllis N.
Australia, Sydney
Royal Prince Alfred Hospital
Callen, David Frederick
Australia, Adelaide
Hanson Institute
Dixon, Joanne W.
New Zealand, Wellington
Wellington Hospital, new Zealand
Kidd, Alexa M.J.
New Zealand, Wellington
Wellington Hospital, new Zealand
Cohen, Paul A.
Unknown Affiliation
Field, Michael J.
Australia, Sydney
Royal North Shore Hospital
Cummings, Margaret C.
Australia, Brisbane
The University of Queensland
DeFazio, Anna
Australia, Sydney
Westmead Hospital
Australia, Parramatta
The Westmead Institute for Medical Research
Dudding, Tracy E.
Unknown Affiliation
Flanagan, James M.
United Kingdom, London
Imperial College London
Gallego-Ortega, David
Australia, Sydney
The Kinghorn Cancer Centre
George, Peter Myles
New Zealand, Christchurch
Canterbury Health Laboratories
Haan, Eric A.
Australia, Adelaide
Women's and Children's Hospital Adelaide
Jenkins, Mark Andrew
Australia, Melbourne
University of Melbourne
Lakhani, Sunil R.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Australia, Brisbane
Royal Brisbane and Women's Hospital
McLachlan, Sue Anne
Australia, Fitzroy
St. Vincent's Hospital Melbourne
Robinson, Bridget Anne
New Zealand, Christchurch
Christchurch Hospital new Zealand
Saunus, Jodi M.
Australia, Brisbane
The University of Queensland
Isaacs, Claudine J.
United States, Washington, D.c.
Georgetown University
Jakubowska, Anna
Poland, Szczecin
Pomeranian Medical University in Szczecin
James, Paul A.
Australia, Melbourne
Peter Maccallum Cancer Centre
Janavičius, Ramūnas
Lithuania, Vilnius
Vilniaus Universitetas
Janni, Wolfgang J.
Germany, Ulm
Universitätsklinikum Ulm
John, Esther M.
United States, Stanford
Stanford University School of Medicine
Jones, Michael E.
United Kingdom, London
The Institute of Cancer Research
Jung, Audrey Y.
Germany, Heidelberg
German Cancer Research Center
Kaaks, Rudolf J.
Germany, Heidelberg
German Cancer Research Center
Karlan, Beth Y.
United States, Los Angeles
Cedars-sinai Medical Center
Khusnutdinova, Ehl'za Kh
Russian Federation, Moscow
Russian Academy of Sciences
Russian Federation, Ufa
Bashkir State Medical University
Kitahara, Cari Meinhold
United States, Rockville
National Cancer Institute Nci
Konstantopoulou, Irene
Greece, Athens
National Centre for Scientific Research Demokritos
Koutros, Stella
United States, Bethesda
National Institutes of Health Nih
Kraft, Peter
United States, Boston
Harvard T.h. Chan School of Public Health
Lambrechts, Diether
Belgium, Ghent
Vlaams Instituut Voor Biotechnologie
Belgium, Leuven
Ku Leuven
Lázaro, Conxi
Spain, Madrid
Centro de Investigación Biomédica en Red de Cáncer
Le Marchand, Loic̈
United States, Honolulu
University of Hawaiʻi Cancer Center
Lester, Jenny
United States, Los Angeles
Cedars-sinai Medical Center
Lesueur, Fabienne El Khoury
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Université Psl
France, Paris
Institut Curie
France, Paris
Mines Paris - Psl
Lilyquist, Jenna
United States, Rochester
Mayo Clinic
Loud, Jennifer T.
United States, Rockville
National Cancer Institute Nci
Lu, Karen H.
United States, Houston
The University of Texas Md Anderson Cancer Center
Luben, Robert N.
United Kingdom, Cambridge
University of Cambridge
Lubiński, Jan
Poland, Szczecin
Pomeranian Medical University in Szczecin
Mannermaa, Arto Msci
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Manoukian, Siranoush
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Margolin, Sara J.
Sweden, Stockholm
Södersjukhuset
Martens, J. W. M. W.M.
Netherlands, Rotterdam
Erasmus Mc Cancer Institute
Mavroudis, Dimitris A.
Greece, Heraklion
Heraklion University Hospital
Mebirouk, Noura
France, Paris
Cancer et Génome : Bioinformatique, Biostatistiques et Épidémiologie Des Systèmes Complexes
France, Paris
Université Psl
France, Paris
Institut Curie
France, Paris
Mines Paris - Psl
Meindl, Alfons
Germany, Munich
Ludwig-maximilians-universität München
Menon, Usha
United Kingdom, London
Mrc Clinical Trials Unit
Miller, Austin
United States, Buffalo
Roswell Park Cancer Institute
Montagna, Marco
Italy, Padua
Istituto Oncologico Veneto Iov - Irccs
Nathanson, Katherine L.
United States, Philadelphia
University of Pennsylvania
Floris, Giuseppe L.
United States, Duarte
City of Hope National Med Center
Newman, William G.
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
United Kingdom, Manchester
Health Innovation Manchester
Nielsen, Finn Cilius
Denmark, Copenhagen
Copenhagen University Hospital
Nielsen, Sarah M.
United States, Chicago
The University of Chicago
Offit, Kenneth
United States, New York
Memorial Sloan-kettering Cancer Center
Oláh, Edith
Hungary, Budapest
Országos Onkológiai Intézet Budapest
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Olshan, Andrew F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Olson, Janet E.
United States, Rochester
Mayo Clinic
Osorio, Ana
Spain, Madrid
Centro Nacional de Investigaciones Oncológicas
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Ottini, Laura
Italy, Rome
Sapienza Università Di Roma
Peto, Julian
United Kingdom, London
London School of Hygiene & Tropical Medicine
Presneau, Nadège
United Kingdom, London
University of Westminster
Pujana, Miguel Àngel G.
Spain, Madrid
Centro de Investigación Biomédica en Red de Cáncer
Punie, Kevin
Belgium, Leuven
Leuvens Kankerinstituut
Rantala, Johanna
Sweden, Stockholm
Karolinska Institutet
Rashid, Muhammad Usman
Germany, Heidelberg
German Cancer Research Center
Pakistan, Lahore
Shaukat Khanum Memorial Cancer Hospital and Research Centre
Rennert, Gad
Israel, Haifa
Carmel Medical Center
Lejbkowicz, Flavio
Israel, Haifa
Carmel Medical Center
Romero, Atocha J.
Spain, Majadahonda
Hospital Universitario Puerta de Hierro Majadahonda
Rookus, Matti A.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Ross, Eric A.
United States, Philadelphia
Fox Chase Cancer Center
Rossing, Maria Caroline
Denmark, Copenhagen
Copenhagen University Hospital
Ruebner, Matthias
Unknown Affiliation
Saloustros, Emmanouil
Greece, Larissa
University Hospital of Larissa
Schmutzler, Rita Katharina
Germany, Koln
Uniklinik Köln
Germany, Koln
Universität zu Köln
Scott, Christopher G.
United States, Rochester
Mayo Clinic
Shah, Mitul N.
United Kingdom, Cambridge
University of Cambridge
Sharma, Priyanka
United States, Kansas City
University of Kansas Medical Center
Shu, Xiaoou
United States, Nashville
Vanderbilt University School of Medicine
Simard, Jacques
Canada, Quebec
Université Laval
Singer, Christian Fridolin
Austria, Vienna
Medizinische Universität Wien
Soucy, Penny
Canada, Quebec
Université Laval
Southey, Melissa Caroline
Australia, Clayton
Monash Health
Australia, Melbourne
University of Melbourne
Spinelli, J. J.
Canada, Vancouver
British Columbia Cancer Agency
Canada, Vancouver
The University of British Columbia
Steele, Linda
United States, Duarte
City of Hope National Med Center
Stoppa-Lyonnet, Dominique
France, Paris
Institut Curie
France, Paris
Cancer, Hétérogénéité, Instabilité et Plasticité Chip
France, Paris
Université Paris Cité
Tapper, William J.
United Kingdom, Southampton
University of Southampton
Teixeira, Manuel Rodrigues
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Portugal, Porto
Universidade do Porto
Thomassen, Mads Christella L.G.D.
Denmark, Odense
Odense Universitetshospital
Tischkowitz, Marc D.
Canada, Montreal
Université Mcgill
United Kingdom, Cambridge
University of Cambridge
Tollenaar, Rob A.E.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Torres, D. M.
Germany, Heidelberg
German Cancer Research Center
Colombia, Bogota
Pontificia Universidad Javeriana
Troester, Melissa A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Truong, Thérèse
France, Gif-sur-yvette
Université Paris-saclay
Tung, Nadine M.
United States, Boston
Beth Israel Deaconess Medical Center
Untch, Michael M.
Unknown Affiliation
Vachon, Celine M.
United States, Rochester
Mayo Clinic
van Rensburg, Elizabeth J.
South Africa, Pretoria
University of Pretoria
van Veen, Elke Maria
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
United Kingdom, Manchester
Health Innovation Manchester
Vega, Ana Karina
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Spain, Santiago de Compostela
Fundación Pública Galega de Medicina Xenómica
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Viel, Alessandra
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Wappenschmidt, Barbara
Germany, Koln
Uniklinik Köln
Germany, Koln
Universität zu Köln
Weitzel, Jeffrey Nelson
United States, Duarte
City of Hope National Med Center
Wieme, Greet
Belgium, Ghent
Universiteit Gent
Wolk, Alicja
Sweden, Stockholm
Karolinska Institutet
Sweden, Uppsala
Uppsala Universitet
Zheng, Wei
United States, Nashville
Vanderbilt University School of Medicine
Ziogas, Argyrios
United States, Irvine
University of California, Irvine
Zorn, Kristin K.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Dunning, Alison M.
United Kingdom, Cambridge
University of Cambridge
Lush, Michael J.
United Kingdom, Cambridge
University of Cambridge
Wang, Qin
United Kingdom, Cambridge
University of Cambridge
McGuffog, Lesley
United Kingdom, Cambridge
University of Cambridge
Parsons, Michael T.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Pharoah, Paul D.P.
United Kingdom, Cambridge
University of Cambridge
Fostira, Florentia
Greece, Athens
National Centre for Scientific Research Demokritos
Toland, Amanda Ewart
United States, Columbus
The Ohio State University
Andrulis, Irene L.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Canada, Toronto
University of Toronto
Ramus, Susan J.
Australia, Sydney
Unsw Sydney
Australia, Sydney
The Kinghorn Cancer Centre
Swerdlow, Anthony J.
United Kingdom, London
The Institute of Cancer Research
Greene, Mark H.
United States, Rockville
National Cancer Institute Nci
Chung, Wendy Kay
United States, New York
Columbia University
Milne, Roger L.
Australia, Melbourne
University of Melbourne
Australia, East Melbourne
Cancer Council Victoria
Australia, Clayton
Monash Health
Chenevix-Trench, Georgia
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Dörk, Thilo
Germany, Hannover
Hannover Medical School
Schmidt, Marjanka K.
Netherlands, Amsterdam
The Netherlands Cancer Institute
Easton, Douglas F.
United Kingdom, Cambridge
University of Cambridge
Radice, Paolo
Italy, Milan
Fondazione Irccs Istituto Nazionale Dei Tumori, Milan
Hahnen, Eric T.
Germany, Koln
Uniklinik Köln
Germany, Koln
Universität zu Köln
Antoniou, Antonis C.
United Kingdom, Cambridge
University of Cambridge
Couch, Fergus J.
United States, Rochester
Mayo Clinic
Nevanlinna, Heli A.
Finland, Helsinki
Helsinki University Hospital
Surrallés, Jordi
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Peterlongo, Paolo
Italy, Milan
Fondazione Ifom Istituto Firc Di Oncologia Molecolare
Statistics
Citations: 26
Authors: 365
Affiliations: 219
Identifiers
Doi:
10.1038/s41523-019-0127-5
ISSN:
23744677
Research Areas
Cancer
Genetics And Genomics
Health System And Policy