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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Delayed-type hypersensitivity to sand fly saliva in humans from a leishmaniasis-endemic area of mali is T
H
1-mediated and persists to midlife
Journal of Investigative Dermatology, Volume 133, No. 2, Year 2013
Notification
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Description
Immunity to sand fly saliva in rodents induces a TH1 delayed-type hypersensitivity (DTH) response conferring protection against leishmaniasis. The relevance of DTH to sand fly bites in humans living in a leishmaniasis-endemic area remains unknown. Here, we describe the duration and nature of DTH to sand fly saliva in humans from an endemic area of Mali. DTH was assessed at 24, 48, 72, and 96 hours post bite in volunteers exposed to colony-bred sand flies. Dermal biopsies were obtained 48 hours post bite; cytokines were quantified from peripheral blood mononuclear cells (PBMCs) stimulated with sand fly saliva in vitro. A DTH response to bites was observed in 75% of individuals aged 1-15 years, decreasing gradually to 48% by age 45, and dropping to 21% thereafter. Dermal biopsies were dominated by T lymphocytes and macrophages. Abundant expression of IFN-γ and absence of T H2 cytokines establishes the TH1 nature of this DTH response. PBMCs from 98% of individuals responded to sand fly saliva. Of these, 23% were polarized to a TH1 and 25% to a TH2 response. We demonstrate the durability and TH1 nature of DTH to sand fly bites in humans living in a cutaneous leishmaniasis-endemic area. A systemic T H2 response may explain why some individuals remain susceptible to disease. © 2013 The Society for Investigative Dermatology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3529997/bin/jid2012315x1.pdf
Authors & Co-Authors
Oliveira, F.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Traoré, Bourama
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Gomes, Regis Bernardo Brandim
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Faye, Ousmane C.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Mali, Bamako
Centre National D'appui à la Lutte Contre la Maladie
Gilmore, Dana C.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Kéïta, Somita M.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Mali, Bamako
Centre National D'appui à la Lutte Contre la Maladie
Traoré, Pierre
Mali, Bamako
Centre National D'appui à la Lutte Contre la Maladie
Teixeira, Clarissa
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Coulibaly, Cheick Amadou
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Samake, Sibiry
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Meneses, Claudio
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Sissoko, Ibrahim Moussa
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Fairhurst, Rick M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Fay, Michael P.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Anderson, Jennifer M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Doumbia, Seydou O.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Kamhawi, Shaden A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Valenzuela, Jesús G.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 50
Authors: 18
Affiliations: 3
Identifiers
Doi:
10.1038/jid.2012.315
ISSN:
0022202X
e-ISSN:
15231747
Study Locations
Mali