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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Plasma creatinine as a determinant of plasma total homocysteine concentrations in the Hordaland Homocysteine Study: Use of statistical modeling to determine reference limits
Clinical Biochemistry, Volume 40, No. 16-17, Year 2007
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Description
Objectives: We established population-based reference limits for plasma total homocysteine (tHcy) according to creatinine. Design and methods: In 7042 middle-aged and elderly subjects from the Hordaland Homocysteine Study, we used statistical modeling to establish nomograms for tHcy according to creatinine in the whole population and in folate-replete and healthy subgroups. Results: When plotted against creatinine, tHcy 97.5th percentile almost overlapped in men and women, and, in elderly, increased up to 8 μmol/L from the 2.5th to 97.5th creatinine percentiles. Folate-replete subjects had tHcy upper limits ∼ 20% below the whole population at all creatinine levels. Healthy subjects had lower creatinine, but at a given creatinine level, tHcy was the same as in the whole population. Conclusions: tHcy difference between men and women is mostly explained by creatinine. The tHcy-reducing effect of folate is independent of creatinine. In elderly people, creatinine should be taken into account when assessing tHcy levels. © 2007 The Canadian Society of Clinical Chemists.
Authors & Co-Authors
Elshorbagy, Amany K.
United Kingdom, Oxford
University of Oxford
Oulhaj, Abderrahim
United Kingdom, Oxford
University of Oxford
Nurk, Eha
Norway, Oslo
Universitetet I Oslo
Ueland, Per Magne
Norway, Bergen
Universitetet I Bergen
Tell, Grethe Seppola
Norway, Bergen
Universitetet I Bergen
Nygård, Ottar Kjell
Norway, Bergen
Universitetet I Bergen
Vollset, Stein Emil
Norway, Bergen
Universitetet I Bergen
Norway, Oslo
Folkehelseinstituttet
Refsum, Helga M.
United Kingdom, Oxford
University of Oxford
Norway, Oslo
Universitetet I Oslo
Statistics
Citations: 15
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.clinbiochem.2007.07.014
ISSN:
00099120
Study Design
Cross Sectional Study
Participants Gender
Male
Female