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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Requisite role for the dectin-1 β-glucan receptor in pulmonary defense against aspergillus fumigatus
Journal of Immunology, Volume 182, No. 8, Year 2009
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Description
Immune suppression increases the incidence of invasive fungal infections, particularly those caused by the opportunistic mold Aspergillus fumigatus. Previous investigations revealed that members of the TLR family are not absolutely required for host defense against A. fumigatus in nonimmunosuppressed hosts, suggesting that other pattern recognition receptors are involved. We show in this study that naive mice (i.e., not pharmacologically immunosuppressed) lacking the β-glucan receptor Dectin-1 (Dectin-1 -/-) are more sensitive to intratracheal challenge with A. fumigatus than control mice, exhibiting >80% mortality within 5 days, ultimately attributed to a compromise in respiratory mechanics. In response to A. fumigatus challenge, Dectin-1-/- mice demonstrated impaired IL-1α, IL-1β, TNF-α, CCL3/MIP-1α, CCL4/MIP-1β, and CXCL1/KC production, which resulted in insufficient lung neutrophil recruitment and uncontrolled A. fumigatus lung growth. Alveolar macrophages from Dectin-1 -/- mice failed to produce proinflammatory mediators in response to A. fumigatus, whereas neutrophils from Dectin-1-/- mice had impaired reactive oxygen species production and impaired killing of A. fumigatus. We further show that IL-17 production in the lung after A. fumigatus challenge was Dectin-1 dependent, and that neutralization of IL-17 significantly impaired A. fumigatus clearance. Collectively, these results support a requisite role for Dectin-1 in in vivo defense against A. fumigatus. Copyright © 2009 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Werner, Jessica L.
United States, Birmingham
The University of Alabama at Birmingham
Metz, Allison E.
United States, Birmingham
The University of Alabama at Birmingham
Horn, Dawn C.
United States, Birmingham
The University of Alabama at Birmingham
Schoeb, Trenton R.
United States, Birmingham
The University of Alabama at Birmingham
Hewitt, Matthew M.
United States, Birmingham
The University of Alabama at Birmingham
Schwiebert, Lisa M.
United States, Birmingham
The University of Alabama at Birmingham
Faro-Trindade, Inês
South Africa, Cape Town
University of Cape Town
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Steele, Chad
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 414
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.4049/jimmunol.0804250
ISSN:
00221767
e-ISSN:
15506606
Study Design
Cohort Study