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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry
Carcinogenesis, Volume 33, No. 4, Year 2012
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Description
Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) in populations of European and Asian ancestry using array chips optimized for populations of European ancestry. It is important to examine whether these loci are associated with breast cancer risk in women of African ancestry. We evaluated 25 single nucleotide polymorphisms (SNPs) at 19 loci in a pooled case-control study of breast cancer, which included 1509 cases and 1383 controls. Cases and controls were enrolled in Nigeria, Barbados and the USA; all women were of African ancestry. We found significant associations for three SNPs, which were in the same direction and of similar magnitude as those reported in previous fine-mapping studies in women of African ancestry. The allelic odds ratios were 1.24 [95% confidence interval (CI): 1.04-1.47; P = 0.018] for the rs2981578-G allele (10q26/FGFR2), 1.34 (95% CI: 1.10-1.63; P = 0.0035) for the rs9397435-G allele (6q25) and 1.12 (95% CI: 1.00-1.25; P = 0.04) for the rs3104793-C allele (16q12). Although a significant association was observed for an additional index SNP (rs3817198), it was in the opposite direction to prior GWAS studies. In conclusion, this study highlights the complexity of applying current GWAS findings across racial/ethnic groups, as none of GWAS-identified index SNPs could be replicated in women of African ancestry. Further fine-mapping studies in women of African ancestry will be needed to reveal additional and causal variants for breast cancer. © The Author 2012. Published by Oxford University Press. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3324445/bin/supp_33_4_835__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3324445/bin/supp_bgs093_Resubmitted_SupplementTables.doc
Authors & Co-Authors
Huo, Dezheng
United States, Chicago
The University of Chicago
Zheng, Yonglan
United States, Chicago
The University of Chicago
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University of Ibadan
Adebamowo, Clement
United States, Baltimore
University of Maryland, Baltimore Umb
Nathanson, Katherine L.
United States, Philadelphia
University of Pennsylvania
Domchek, Susan M.
United States, Philadelphia
University of Pennsylvania
Rebbeck, Timothy R.
United States, Philadelphia
University of Pennsylvania
Simon, Michael S.
United States, Detroit
Wayne State University
John, Esther M.
United States, Stanford
Stanford Cancer Institute
United States, Fremont
Cancer Prevention Institute of California
Hennis, Anselm J.M.
Jamaica, Kingston
The University of the West Indies
Nemesure, Barbara Berger
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Wu, Suhyuh
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Leske, Maria Cristina
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Ambs, Stefan
United States, Rockville
National Cancer Institute Nci
Niu, Qun
United States, Chicago
The University of Chicago
Zhang, Jing
United States, Chicago
The University of Chicago
Cox, Nancy Jean
United States, Chicago
The University of Chicago
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Statistics
Citations: 74
Authors: 18
Affiliations: 10
Identifiers
Doi:
10.1093/carcin/bgs093
ISSN:
01433334
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Study Locations
Nigeria
Participants Gender
Female