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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Lung-resident CD4
+
T cells are sufficient for IL-4R-dependent recall immunity to Nippostrongylus brasiliensis infection
Mucosal Immunology, Volume 7, No. 2, Year 2014
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Description
Immunity to Nippostrongylus brasiliensis reinfection requires pulmonary CD4+ T-cell responses. We examined whether secondary lymphoid recruited or pre-existing lung CD4+ T-cell populations coordinated this immunity. To do this, we blocked T-cell egress from lymph nodes using Fingolimod (FTY720). This impaired host ability to resolve a primary infection but did not change effectiveness of recall immunity. Associated with this effective recall immunity was the expansion and T helper type 2 polarization of a pre-existing pulmonary CD4+ T-cell population. LTβR-Ig (lymphotoxin beta-receptor fusion protein)-mediated disruption of stromal cell organization of immune cells did not disrupt this recall immunity, suggesting that protection was mediated by a pulmonary interstitial residing CD4 + T-cell population. Adoptive transfer of N. brasiliensis-experienced pulmonary CD4 + T cells from FTY720-treated wild-type or T-cell interleukin (IL)-4R-deficient mice demonstrated protection to be IL-4R dependent. These results show that pre-existing CD4+ T cells can drive effective recall immunity to N. brasiliensis infection independently of T-cell recruitment from secondary lymphoid organs. © 2014 Society for Mucosal Immunology.
Authors & Co-Authors
Thawer, Sumaiyya G.
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Belgium, Sart Tilman
Faculty of Veterinary Medicine
Horsnell, William Gordon Charles
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Belgium, Sart Tilman
Faculty of Veterinary Medicine
Darby, Matthew G.
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Hoving, Jennifer Claire
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Dewals, Benjamin G.
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Cutler, Antony J.
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
United Kingdom, Cambridge
Cambridge Institute for Medical Research
Lang, Dirk M.
South Africa, Cape Town
Faculty of Health Sciences
Brombacher, Frank
Italy, Trieste
International Centre for Genetic Engineering and Biotechnology
Statistics
Citations: 43
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1038/mi.2013.40
ISSN:
19330219
e-ISSN:
19353456
Study Design
Cross Sectional Study