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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antimicrobial resistance determinants and susceptibility profiles of pneumococcal isolates recovered in Trinidad and Tobago
Journal of Global Antimicrobial Resistance, Volume 11, Year 2017
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Description
Objectives In Latin America and the Caribbean, pneumococcal infections are estimated to account for 12 000–18 000 deaths, 327 000 pneumonia cases, 4000 meningitis cases and 1229 sepsis cases each year in children under five years old. Pneumococcal antimicrobial resistance has evolved into a worldwide health problem in the last few decades. This study aimed to determine the antimicrobial susceptibility profiles of pneumococcal isolates collected in Trinidad and Tobago and their associated genetic determinants. Methods Whole-genome sequences were obtained from 98 pneumococcal isolates recovered at several regional hospitals, including 83 invasive and 15 non-invasive strains, recovered before (n = 25) and after (n = 73) introduction of pneumococcal conjugate vaccines (PCVs). A bioinformatics pipeline was used to identify core genomic and accessory elements conferring antimicrobial resistance phenotypes, including β-lactam non-susceptibility. Results and discussion Forty-one isolates (41.8%) were predicted as resistant to at least one antimicrobial class, including 13 (13.3%) resistant to at least three classes. The most common serotypes associated with antimicrobial resistance were 23F (n = 10), 19F (n = 8), 6 B (n = 6) and 14 (n = 5). The most common serotypes associated with penicillin non-susceptibility were 19F (n = 7) and 14 (n = 5). Thirty-nine isolates (39.8%) were positive for PI-1 or PI-2 type pili: 30 (76.9%) were PI-1+, 4 (10.3%) were PI-2+ and 5 (12.8%) were positive for both PI-1 and PI-2. Of the 13 multidrug-resistant isolates, 10 belonged to globally distributed clones PMEN3 and PMEN14 and were isolated in the post-PCV period, suggesting clonal expansion. © 2017 The Author(s)
Authors & Co-Authors
Hawkins, Paulina A.
United States, Atlanta
Emory University
United States, Atlanta
Centers for Disease Control and Prevention
Akpaka, Patrick Eberechi
Trinidad and Tobago, St Augustine
The University of the West Indies, St. Augustine Campus
Nurse-Lucas, Michele
Trinidad and Tobago, St Augustine
The University of the West Indies, St. Augustine Campus
Gladstone, Rebecca A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Bentley, Stephen D.
United Kingdom, Hinxton
Wellcome Sanger Institute
Breiman, Robert F.
United States, Atlanta
Emory University
McGee, Lesley
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 6
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.jgar.2017.08.004
ISSN:
22137165
Research Areas
Genetics And Genomics
Maternal And Child Health