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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HBV lamivudine resistance among hepatitis B and HIV coinfected patients starting lamivudine, stavudine and nevirapine in Kenya
Journal of Viral Hepatitis, Volume 18, No. 10, Year 2011
Notification
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Description
Widespread use of lamivudine in antiretroviral therapy may lead to hepatitis B virus resistance in HIV-HBV coinfected patients from endemic settings where tenofovir is not readily available. We evaluated 389 Kenyan HIV-infected adults before and for 18 months after starting highly active antiretroviral therapy with stavudine, lamivudine and nevirapine. Twenty-seven (6.9%) were HBsAg positive and anti-HBs negative, 24 were HBeAg negative, and 18 had HBV DNA levels ≤10 000 IU/mL. Sustained HBV suppression to <100 IU/mL occurred in 89% of 19 evaluable patients. Resistance occurred in only two subjects, both with high baseline HBV DNA levels. Lamivudine resistance can emerge in the setting of incomplete HBV suppression but was infrequently observed among HIV-HBV coinfected patients with low baseline HBV DNA levels. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Nina Kim, Hyang Nina
United States, Cincinnati
Departments of Medicine
Scott, John D.
United States, Cincinnati
Departments of Medicine
Cent, Anne
United States, Seattle
University of Washington
Cook, Linda
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Ashley, Rhoda L.
United States, Seattle
University of Washington
Richardson, Barbra Ann
United States, Seattle
University of Washington
Tapia, Kenneth A.
United States, Seattle
University of Washington
Jerome, Keith R.
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Lule, Godfrey Nsereko
Kenya, Nairobi
University of Nairobi
John-Stewart, Grace C.
United States, Cincinnati
Departments of Medicine
United States, Seattle
University of Washington
Chung, Michael Hoonbae
United States, Cincinnati
Departments of Medicine
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Statistics
Citations: 25
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-2893.2011.01466.x
ISSN:
13520504
e-ISSN:
13652893
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Kenya