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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Artery Research, Volume 29, No. 3, Year 2023
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Description
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular leakage and edema formation. This study examined alterations in the circulation of patients with mild and severe COVID-19 on in vitro endothelial permeability and its relation to the endothelial angiopoietin/Tie2 system, which is involved in the regulation of endothelial permeability. Plasma was obtained from COVID-19 patients admitted to the ward (n = 14) or ICU (n = 20) at admission and after 1 and 2 weeks and healthy controls (n = 5). Human kidney and lung endothelial cells were exposed to patient plasma and treated with recombinant angiopoietin-1. In vitro endothelial barrier function was assessed using electric cell-substrate impedance sensing. Circulating markers of the angiopoietin/Tie2 system, endothelial dysfunction and glycocalyx degradation were measured by ELISA. Plasma from COVID-19 patients reduced endothelial resistance compared to healthy controls, but COVID-19 plasma-induced drop in endothelial resistance did not differ between ward and ICU patients. Circulating angiopoietin-2, soluble Tie2 and soluble Tie1 levels increased over time in ICU patients, whereas levels remained stable in ward patients. The increase in angiopoietin-2 was able to predict 90-day mortality (AUC = 0.914, p < 0.001). Treatment with recombinant angiopoietin-1 did not restore COVID-19 plasma-induced hyperpermeability. In conclusion, these results suggest that indirect effects of the virus represented in the circulation of COVID-19 patients induced endothelial hyperpermeability irrespective of disease severity and changes in the endothelial angiopoietin/Tie2 system. Nonetheless, angiopoietin-2 might be of interest in the context of organ injury and patient outcome in COVID-19. © 2023, The Author(s).
Authors & Co-Authors
van Amstel, Rombout Benjamin Ezra
Unknown Affiliation
van Baarle, Frank E.F.P.
Unknown Affiliation
Bonta, Peter I.
Unknown Affiliation
Bos, Lieuwe D.J.
Unknown Affiliation
de Brabander, Justin
Unknown Affiliation
de Bree, Godelieve J.
Unknown Affiliation
de Bruin, Sanne
Unknown Affiliation
Bugiani, Marianna
Unknown Affiliation
Geerlings, Suzanne Eugenie
Unknown Affiliation
Goorhuis, Abram
Unknown Affiliation
Grobusch, Martín Peter
Unknown Affiliation
Hagens, Laura A.
Unknown Affiliation
Harris, Vanessa C.
Unknown Affiliation
Hermans, S. M.
Unknown Affiliation
Heunks, Leo M.A.
Unknown Affiliation
Hollmann, Markus Wiersma
Unknown Affiliation
Horn, Janneke
Unknown Affiliation
Hovius, Joppe Willem R.
Unknown Affiliation
de Jong, Menno Douwe
Unknown Affiliation
Koning, Rutger
Unknown Affiliation
Lim, Endry H.T.
Unknown Affiliation
Nossent, Esther J.
Unknown Affiliation
Peters, Edgar J.
Unknown Affiliation
Prins, Jan M.
Unknown Affiliation
Sigaloff, Kim Catherina Eve
Unknown Affiliation
Slim, Marleen A.
Unknown Affiliation
Smeele, Patrick J.
Unknown Affiliation
Smit, Marry R.
Unknown Affiliation
Tuinman, Pieter Roel
Unknown Affiliation
Veelo, Denise Petra
Unknown Affiliation
van Vught, Lonneke Alette V.
Unknown Affiliation
van Vugt, Michèle V.
Unknown Affiliation
Zwinderman, Aeilko Having Koos
Unknown Affiliation
Brouwer, Matthijs C.
Unknown Affiliation
Wiersinga, Willem Joost
Unknown Affiliation
Statistics
Authors: 35
Affiliations: 2
Identifiers
Doi:
10.1007/s44200-023-00036-2
ISSN:
18729312
Research Areas
Covid
Health System And Policy
Violence And Injury