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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identity by descent and DNA sequence variation of human SINE and LINE elements
Cytogenetic and Genome Research, Volume 108, No. 1-3, Year 2005
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Description
To test the hypothesis that Alu and L1 elements are genetic characters that are essentially homoplasy-free, we sequenced a total of five human L1 elements and eleven recently integrated Alu elements from 160 chromosomes (80 individuals representing four diverse human populations). Analysis of worldwide samples at L1 loci revealed 292 segregating sites and a nucleotide diversity of 0.0050. For Ya5 Alu loci, there were 129 segregating sites and nucleotide diversity was estimated at 0.0045. The Alu and L1 sequence diversity varied element to element. No completely or partially deleted Alu or L1 alleles were identified during the analysis. These data suggest that mobile element insertions are identical by descent characters for the study of human population genetics. Copyright © 2005 S. Karger AG, Basel.
Authors & Co-Authors
Salem, Abdel Halim
United States, Baton Rouge
Louisiana State University
Egypt, Ismailia
Faculty of Medicine
Ray, David A.
United States, Baton Rouge
Louisiana State University
Batzer, Mark A.
United States, Baton Rouge
Louisiana State University
Statistics
Citations: 30
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1159/000080803
ISSN:
14248581
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study