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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Social networks and inflammatory markers in the Framingham heart study
Journal of Biosocial Science, Volume 38, No. 6, Year 2006
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Description
Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1). Participants in the Framingham Study attending examinations from 1998 to 2001 (n=3267) were eligible for inclusion in the study. Social networks were assessed using the Berkman-Syme Social Network Index (SNI). Concentrations of IL-6, CRP, sICAM-1 and MCP-1 were measured in fasting serum samples. Multivariable linear regression analyses were used to assess the association of social networks with inflammatory markers adjusting for potential confounders including age, smoking, blood pressure, total:HDL cholesterol ratio, body mass index, lipid-lowering and antihypertensive medication, diabetes, cardiovascular disease, depression and socioeconomic status. Results found that the SNI was significantly inversely associated with IL-6 in men (p=0.03) after adjusting for potential confounders. In age-adjusted analyses, social networks also were significantly inversely associated with IL-6 for women (p=0.03) and were marginally to modestly associated with CRP and sICAM-1 for men (p=0.08 and 0.02, respectively), but these associations were not significant in the multivariate analyses. In conclusion, social networks were found to be inversely associated with interleukin-6 levels in men. The possibility that inflammatory markers may be potential mediators between social integration and coronary heart disease merits further investigation. © 2006 Cambridge University Press.
Authors & Co-Authors
Sullivan, Lisa M.
United States, Boston
Boston University
D’Agostino, Ralph B.
United States, Boston
Boston University
United States, Framingham
Framingham Heart Study
Larson, Martin G.
United States, Boston
Boston University
United States, Framingham
Framingham Heart Study
Berkman, Lisa F.
United States, Boston
Harvard T.h. Chan School of Public Health
Benjamin, Emelia J.
United States, Boston
Boston University
United States, Framingham
Framingham Heart Study
Statistics
Citations: 189
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1017/S0021932005001203
ISSN:
14697599
Research Areas
Mental Health
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Male
Female