Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Neonatal BCG vaccination influences cytokine responses to toll-like receptor ligands and heterologous antigens
Journal of Infectious Diseases, Volume 217, No. 11, Year 2018
Notification
URL copied to clipboard!
Description
Background. BCG vaccination is associated with a reduction in all-cause infant mortality in high-mortality settings. The underlying mechanisms remain uncertain, but long-term modulation of the innate immune response (trained immunity) may be involved. Methods. Whole-blood specimens, collected 7 days after randomization from 212 neonates enrolled in a randomized trial of neonatal BCG vaccination, were stimulated with killed pathogens and Toll-like receptor (TLR) ligands to interrogate cytokine responses. Results. BCG-vaccinated infants had increased production of interleukin 6 (IL-6) in unstimulated samples and decreased production of interleukin 1 receptor antagonist, IL-6, and IL-10 and the chemokines macrophage inflammatory protein 1α (MIP-1α), MIP-1β, and monocyte chemoattractant protein 1 (MCP-1) following stimulation with peptidoglycan (TLR2) and R848 (TLR7/8). BCG-vaccinated infants also had decreased MCP-1 responses following stimulation with heterologous pathogens. Sex and maternal BCG vaccination status interacted with neonatal BCG vaccination. Conclusions. Neonatal BCG vaccination influences cytokine responses to TLR ligands and heterologous pathogens. This effect is characterized by decreased antiinflammatory cytokine and chemokine responses in the context of higher levels of IL-6 in unstimulated samples. This supports the hypothesis that BCG vaccination modulates the innate immune system. Further research is warranted to determine whether there is an association between these findings and the beneficial nonspecific (heterologous) effects of BCG vaccine on all-cause mortality. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Freyne, Bridget Joan
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Donath, Susan M.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Germano, Susie
Australia, Melbourne
Murdoch Children's Research Institute
Gardiner, Kaya Kareela
Australia, Melbourne
Murdoch Children's Research Institute
Casalaz, Dan M.
Australia, Melbourne
Mercy Hospital for Women
Robins-Browne, Roy Michael
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
Amenyogbe, Nelly A.
Canada, Vancouver
The University of British Columbia
Messina, Nicole L.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Flanagan, Katie L.
Australia, Hobart
Tasmanian School of Medicine
Australia, Clayton
Monash University
Kollmann, Tobias R.
Canada, Vancouver
The University of British Columbia
Curtis, Nigel C.
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
Royal Children's Hospital, Melbourne
Statistics
Citations: 64
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1093/infdis/jiy069
ISSN:
00221899
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial