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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Impact of diabetes mellitus on clinical presentation and prognosis of pancreatic cancer
Annales d'Endocrinologie, Volume 72, No. 1, Year 2011
Notification
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Description
Introduction: The aim of this study was to investigate possible effects of diabetes mellitus on clinical manifestations and prognosis of pancreatic cancer (PC). Patients and methods: We retrospectively reviewed the clinical files of 122 patients with PC, and divided them into two groups: those with diabetes (56 patients) and those without diabetes (66 patients). The two groups were then compared for demographic profiles, clinical manifestations of PC, features of the tumor and fatal outcomes. Results: Mean age, sex distribution, body mass index at cancer diagnosis, prevalence of hypertension, dyslipidemia, weight loss, abdominal pain, lumbar pain, signs of dyspepsia, and size, and histological features of the tumor were similar between the two groups. The cancer was located in the head of the pancreas in 50% of those with diabetes, and 80% of those without diabetes (P= 0.04). The median survival time was similar. Conclusions: Clinical features, tumor size and prognosis of PC are similar in people with and without diabetes. Having diabetes does not seem to contribute to earlier diagnosis of PC. © 2010 Elsevier Masson SAS.
Authors & Co-Authors
Dehayem, Mesmin Yefou
Cameroon, Yaounde
Hopital Central de Yaounde
Phelip, J. M.
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Kengne, Andre-Pascal Pascal
Australia, Sydney
The University of Sydney
Choukem, Siméon Pierre
Cameroon, Douala
Hopital General de Douala
Benhamou, Pierre Yves
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
Halimi, Serge
France, Grenoble
Centre Hospitalier Universitaire de Grenoble
Statistics
Citations: 10
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.ando.2010.10.001
ISSN:
00034266
Research Areas
Cancer
Noncommunicable Diseases
Study Design
Cross Sectional Study