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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vaccination aginst chronic viral carriage in The Gambia
The Lancet, Volume 337, No. 8744, Year 1991
Notification
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Description
358 children in the Gambian villages of Keneba and Manduar, where hepatitis B virus (HBV) infection is endemic, were vaccinated with plasma-derived vaccine against HBV according to one of four regimens and followed for up to 4 years. Two regimens by which vaccine was injected intradermally into children between 0 and 4 years old led to peak geometric mean (95% Cl) concentrations of antibody against HBV surface antigen of 270 (202-358) and 555 (418-748) mlU/ml. The third regimen-intramuscular vaccination of children aged between 0 and 4 years-gave geometric mean peak antibody concentrations of 926 (765-1122) mlU/ml. A fourth regimen was intramuscular vaccination of children between 1 and 9 months old, which gave geometric mean antibody concentrations of 5431 (3903-75 456) mlU/ml. Despite these widely divergent responses and a 89% decay in antibody over the first 2 years, vaccination against HBV was 97% effective in preventing chronic infection. Vaccination was less effective in preventing uncomplicated infection: 5·3% of 264 vaccinees in Keneba and 19·1% of 94 vaccinees in Manduar tested positive for antibody to HBV core antigen. These "breakthrough infections" did not differ in frequency between regimens, and were associated with low initial antibody responses and chronic maternal carriage of HBV. © 1991.
Authors & Co-Authors
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Inskip, Hazel M.
Gambia, Banjul
International Agency for Research on Cancer
Hall, Andrew J.
Gambia, Banjul
International Agency for Research on Cancer
Mendy, Maimuna E.
Gambia, Banjul
International Agency for Research on Cancer
Downes, R.
United Kingdom, Cambridge
Mrc Mitochondrial Biology Unit
Hoare, Simon
United Kingdom, Cambridge
Mrc Mitochondrial Biology Unit
Statistics
Citations: 108
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/0140-6736(91)91367-4
ISSN:
01406736
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Gambia