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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between elevated blood glucose and outcome in acute heart failure: Results from an international observational cohort
Journal of the American College of Cardiology, Volume 61, No. 8, Year 2013
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Description
Objective: The aim of this analysis was to assess the association between elevated blood glucose level and mortality in acute heart failure (AHF). Background: Elevated blood glucose has been reported to be prognostically meaningful in patients with cardiac diagnoses, such as coronary artery disease. The short-term prognostic impact of hyperglycemia in AHF is unknown, however. Methods: In a multinational cohort of AHF, we examined the ability of blood glucose concentrations at presentation to predict all-cause mortality by 30 days. Fully adjusted models for prognosis included a previous diagnosis of diabetes mellitus as a covariate. Results: A total of 6,212 subjects with AHF (mean age, 72 years; 52.5% male) were studied; the median blood glucose concentration on arrival at the hospital was 7.5 mmol/l (135 mg/dl), and 41% had a previous diagnosis of diabetes mellitus (DM). After 30 days, 618 patients (10%) had died. Compared with survivors, decedents had significantly higher median blood glucose concentrations (8.9 mmol/l vs. 7.4 mmol/l; p < 0.0001). In the fully adjusted model, an elevated blood glucose level was an independent predictor of 30-day mortality in AHF (odds ratio: 2.19; 95% confidence interval: 1.69 to 2.83; p < 0.001). The risk associated with an elevated blood glucose level appeared consistent across all subgroups of patients, including patients with preserved (hazard ratio: 5.41; 95% confidence interval: 2.44 to 12.0; p < 0.0001) and impaired systolic function (hazard ratio: 2.37; 95% confidence interval: 1.57 to 3.59; p < 0.0001). Furthermore, in reclassification analyses, elevated blood glucose added significant prognostic information to clinical parameters alone (4.4% net reclassification improvement; p = 0.01). Conclusions: Among patients with AHF, blood glucose concentrations at presentation are powerfully prognostic for 30-day mortality, independent of a diagnosis of diabetes mellitus or other clinical variables. Because blood glucose is easily modifiable, it may represent a valid target for therapeutic intervention. © 2013 American College of Cardiology Foundation.
Authors & Co-Authors
Mebazaa, Alexandre
France, Paris
Hôpital Lariboisiere Ap-hp
France, Paris
Inserm
Gayat, Étienne
France, Paris
Hôpital Lariboisiere Ap-hp
France, Paris
Inserm
Lassus, Johan P.E.
Finland, Helsinki
Helsinki University Hospital
Méas, Taly
France, Paris
Inserm
France, Paris
Hôpital Lariboisiere Ap-hp
Müeller, Christian Eugen
Switzerland, Basel
Universitätsspital Basel
Maggioni, Aldo Pietro
Italy, Florence
Associazione Nazionale Medici Cardiologi Ospedalieri
Peacock IV, William Frank
United States, Cleveland
Cleveland Clinic Foundation
Špinar, Jindřich
Czech Republic, Brno
Fakultni Nemocnice Brno
Harjola, Veli Pekka
Finland, Helsinki
Helsinki University Hospital
van Kimmenade, Roland R.J.
Netherlands, Utrecht
University Medical Center Utrecht
Pathak, Atul
France, Toulouse
Chu de Toulouse
Mueller, Thomas J.
Austria, Vienna
Medizinische Universität Wien
Tavazzi, Luigi T.
Italy, Cotignola
Maria Cecilia Hospital
DiSomma, Salvatore
Italy, Rome
Azienda Ospedaliero-universitaria Sant'andrea
Metra, Marco
Italy, Brescia
Università Degli Studi Di Brescia
Pascual-Figal, Domingo A.
Spain, Murcia
Universidad de Murcia
Laribi, Said
France, Paris
Hôpital Lariboisiere Ap-hp
Logeart, Damien
France, Paris
Inserm
France, Paris
Hôpital Lariboisiere Ap-hp
Nouira, Semir
Tunisia, Monastir
Chu Fattouma-bourguiba
Sato, Naoki
Japan, Kawasaki
Nippon Medical School Musashi-kosugi Hospital
Pařenica, Jiří
Czech Republic, Brno
Fakultni Nemocnice Brno
Deye, Nicolas
France, Paris
Inserm
France, Paris
Hôpital Lariboisiere Ap-hp
Boukef, Riadh
France, Paris
Hôpital Lariboisiere Ap-hp
Collet, Corinne
France, Paris
Inserm
van den Berghe, Greet H.A.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Cohen-Solal, Alain
France, Paris
Inserm
France, Paris
Hôpital Lariboisiere Ap-hp
Januzzi, James Louis
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 115
Authors: 27
Affiliations: 18
Identifiers
Doi:
10.1016/j.jacc.2012.11.054
ISSN:
07351097
e-ISSN:
15583597
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study
Case-Control Study
Participants Gender
Male