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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Behavioral and anticonvulsant effects of the standardized extract of Ficus platyphylla stem bark
Journal of Ethnopharmacology, Volume 154, No. 2, Year 2014
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Description
Ethnopharmacological relevance Decoctions of Ficus platyphylla Del.-Holl (Family: Moraceae) are used in Nigeria's folk medicine for the management of epilepsy and their efficacies are widely acclaimed among the rural communities of northern Nigeria. The aim of the study is to examine the behavioral and anticonvulsant properties of the standardized methanol extract of Ficus platyphylla (FP) stem bark, in order to scientifically describe its potential values in the management of convulsive disorders. Materials and methods High performance liquid chromatography (HPLC) and preliminary phytochemical analysis of the methanol extract were utilized and the intraperitoneal median lethal dose (LD50) determined in mice. The effects of FP were investigated on some murine models of behavior and its anticonvulsant effects studied on pentylenetetrazole (PTZ)-, strychnine (STN)-, picrotoxin (PCT)-, isoniazid (INH)-, aminophylline (AMI)- and maximal electroshock (MES)-induced seizures in mice. Results The intraperitoneal oral LD50 of FP was estimated to be 5000 mg/kg. FP significantly reduced the locomotor activities including the total distance covered, speed, active time and rearing counts. It shortened the onset and prolonged the duration of diazepam-induced sleep, but had no effect on motor coordination on the rota-rod treadmill or beam-walking assay in mice at the doses tested. The extract protected the mice against PTZ- and STN-induced seizures and significantly delayed the latencies of myoclonic jerks and tonic seizures induced by all the standard convulsant agents (PTZ, PCT, INH, STN and AMI) used in this study, but failed to protect the mice against MES seizures at the doses tested. The HPLC fingerprint of the extract shows a spectrum profile characteristic of Ficus platyphylla, while the preliminary phytochemical screening revealed the presence of saponins, flavonoids and tannins. Conclusion Our study provides scientific evidence that FP may contain psychoactive principles with potential anticonvulsant properties, thus supporting further development of the psychoactive components of this plant as anticonvulsant agents. © 2014 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Chindo, Ben Ahmed
Nigeria, Kaduna
Kaduna State University
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Ya’u, Jamilu
Nigeria, Zaria
Ahmadu Bello University
Danjuma, Nuhu Mohammed
Nigeria, Zaria
Ahmadu Bello University
Okhale, Samuel Ehiabhi
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Gamaniel, Karniyus Shingu
Nigeria, Garki
National Institute for Pharmaceutical Research and Development, Nigeria
Becker, Axel
Germany, Magdeburg
Otto-von-guericke-universität Magdeburg
Statistics
Citations: 39
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.jep.2014.03.061
ISSN:
03788741
e-ISSN:
18727573
Research Areas
Health System And Policy
Substance Abuse
Study Locations
Nigeria