Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients
Diabetes and Vascular Disease Research, Volume 10, No. 3, Year 2013
Notification
URL copied to clipboard!
Description
Serum soluble receptor for advanced glycation end product (sRAGE) may reflect the activity of the advanced glycation end product (AGE)-receptor for advanced glycation end product (RAGE) axis, which has been proposed as a potential mechanism linking hyperglycaemia to vascular complications in diabetes. We have investigated whether serum AGEs, sRAGE and pentosidine levels were increased and correlated with microvascular complications in type 2 diabetes mellitus (DM). We included 30 healthy control subjects, and 200 diabetic patients were divided into two subgroups: 100 patients with diabetic retinopathy and 100 patients with diabetic nephropathy. AGEs, sRAGE and pentosidine were measured in serum by enzyme-linked immunosorbent assay (ELISA). Serum AGEs, sRAGE and pentosidine levels were significantly increased in diabetic patients with retinopathy and in diabetic patients with nephropathy compared to control subjects (p < 0.001). Serum AGEs, sRAGE and pentosidine levels are positively associated with microvascular complications in type 2 DM. Multiple regression analysis reveals serum pentosidine as an independent determinant of the presence of diabetic retinopathy (p = 0.004) and the presence of hypertension (p = 0.018) and hyperlipidaemia (p = 0.036). Pentosidine levels may be a biomarker for microvascular complications in type 2 diabetic patients. © The Author(s) 2012.
Authors & Co-Authors
Kerkeni, Mohsen
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Saïdi, Amel
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Bouzidi, Hassan
Tunisia, Mahdia
Chu Tahar Sfar
Letaief, Ahmed
Tunisia, Monastir
Chu Fattouma-bourguiba
Ben-Yahia, Salim
Tunisia, Monastir
Chu Fattouma-bourguiba
Hammami, M. B.
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Statistics
Citations: 84
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1177/1479164112460253
ISSN:
14791641
e-ISSN:
17528984
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative