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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of adenovirus vectors containing serotype 35 fibers for vaccination
Molecular Therapy, Volume 13, No. 4, Year 2006
Notification
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Description
In contrast to commonly used serotype 5-based adenovirus (Ad) vectors, Ad's containing fibers derived from B-group serotype 35 (Ad5/35) efficiently transduce human DCs ex vivo and appear to target antigen-presenting cells after intravenous injection into baboons. Based on this, Ad5/35 vectors could be valuable tools for immunotherapy and vaccination. On the other hand, a number of studies indicate that signaling through the B-group Ad receptor, CD46, can cause tolerance or immunosuppression. Since mice do not express CD46 in a human-like pattern, we studied the in vivo properties of Ad5/35 in transgenic mice that express CD46 in a pattern and at a level similar to those of humans. Hypersensitivity assays and analyses of frequencies of regulatory T cells and T cell responses did not indicate that Ad5/35 injection exerts detrimental effects on the host's immune system. An Ad5/ 35 vector expressing a model antigen was able to trigger a strong T cell response against the test antigen after intramuscular injection. Overall, compared to Ad5 vectors, Ad5/35 vectors had a better safety profile, reflected by lower serum levels of proinflammatory cytokines. Copyright © The American Society of Gene Therapy.
Authors & Co-Authors
DiPaolo, Nelson C.
United States, Seattle
University of Washington
Ni, Shaoheng
United States, Seattle
University of Washington
Gaggar, Anuj
United States, Seattle
University of Washington
Strauss, Robert
United States, Seattle
University of Washington
Tuve, Sebastian
United States, Seattle
University of Washington
Li, Zongyi
United States, Seattle
University of Washington
Stone, Daniel
United States, Seattle
University of Washington
Shayakhmetov, Dmitry M.
United States, Seattle
University of Washington
Kiviat, Nancy B.
United States, Seattle
University of Washington
Touré, Papa Souleymane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sow, Salif Papa
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Horvat, Branka
France, Paris
Inserm
Lieber, André
United States, Seattle
University of Washington
Statistics
Citations: 54
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/j.ymthe.2005.12.008
ISSN:
15250016
Research Areas
Cancer
Genetics And Genomics